脂代谢异常在胰腺癌发生发展中作用的研究进展
Role of lipid metabolism disorders in the occurrence and development of pancreatic cancer:a review of research progress
王云峰 1夏俊伟 1徐白莹1
作者信息
- 1. 上海市浦东新区人民医院 普通外科,上海 201299
- 折叠
摘要
大部分胰腺癌患者确诊时已经出现转移,手术治疗的机会少,化疗和放疗的治疗效果较差,目前急需新的治疗手段.脂代谢异常与胰腺癌发生发展的关系密切,脂代谢异常既是胰腺癌发生的危险因素,也能通过抑制胰腺癌细胞凋亡,增强胰腺癌细胞的代谢与增殖、转移等来加速胰腺癌的发展.笔者就脂代谢异常在胰腺癌相关的进展和关注点进行总结和论述,以期为相关研究提供参考.
Abstract
Most pancreatic cancer patients are diagnosed with metastasis already present,leaving few opportunities for surgical treatment,and chemotherapy and radiotherapy showing poor treatment outcomes.There is an urgent need for new treatment modalities.There is a close relationship between disorders of lipid metabolism and the occurrence and development of pancreatic cancer.Lipid metabolism disorders are not only risk factors for the development of pancreatic cancer but also accelerate the progression of pancreatic cancer by inhibiting apoptosis of pancreatic cancer cells and enhancing their metabolism,proliferation,and metastasis.Here,the authors summarize and discuss the progress and focal points of lipid metabolism disorders in pancreatic cancer,aiming to offer insights for relevant research.
关键词
胰腺肿瘤/脂代谢障碍/综述Key words
Pancreatic Neoplasms/Lipid Metabolism Disorders/Review引用本文复制引用
基金项目
上海市浦东新区卫生系统学科带头人培养计划(PWRd2021-16)
出版年
2024
国家科技期刊平台
NSTL
万方数据