Ⅱ型脱碘酶在甲状腺疾病中的研究进展
Research advance of the type 2 deiodinase in thyroid diseases
许丹晴 1张淼 1周力 2丁金旺 3彭友2
作者信息
- 1. 浙江中医药大学第四临床医学院,浙江杭州 310053
- 2. 西湖大学医学院附属杭州市第一人民医院肿瘤外科,浙江杭州 310006
- 3. 浙江省肿瘤医院甲状腺外科,浙江杭州 310022
- 折叠
摘要
Ⅱ型脱碘酶(D2)是一种重要的含硒蛋白酶,负责将甲状腺素(T4)的外环去碘化,形成生物活性更高的三碘甲状腺素(T3),从而调节体内的新陈代谢、生长发育和能量平衡.D2的活性受到多种因素的调控,包括自身甲状腺激素水平、cAMP途径、泛素化、内质网应激以及环境等.D2不仅与甲状腺疾病的发生、发展密切相关,而且在调节细胞增殖方面具有重要作用,因此被认为可能是有用的癌症标志物.此外,Ⅱ型脱碘酶基因(DIO2)Thr92Ala多态性已被证实是甲状腺疾病的相关因素,了解这种多态性与甲状腺疾病的关系,不仅可以帮助预测个体患病的风险,还有望为个性化治疗提供依据.本综述重点介绍D2的调控机制及其在甲状腺疾病中的重要作用,以及DIO2 Thr92Ala多态性在疾病发展中的影响,为今后的研究与临床实践提供指导.
Abstract
Type Ⅱ deiodinase(D2)is an important selenium-containing protease responsible for the outer ring deiodination of thyroxine(T4)to form the more biologically active triiodothyronine(T3),thereby regulating metabolism,growth and development,and energy balance in the body.D2 activity is regulated by various factors,including thyroid hormone levels,the cAMP pathway,ubiquitination,endoplasmic reticulum stress,and environmental factors.D2 is closely related to the occurrence and development of thyroid diseases and plays a crucial role in regulating cell proliferation,thus it is considered a potential cancer marker.Additionally,the Thr92Ala polymorphism of the type Ⅱ deiodinase gene(DIO2)has been confirmed as a factor related to thyroid diseases.Understanding the relationship between this polymorphism and thyroid diseases can help predict individual disease risk and provide a basis for personalized treatment.This review focuses on the regulatory mechanisms of D2 and its essential role in thyroid diseases,as well as the impact of the DIO2 Thr92Ala polymorphism on disease development,to provide a guidance for future research and clinical praxis.
关键词
甲状腺疾病/碘甲状腺原氨酸二碘酶/T3甲状腺激素/多态性,单核苷酸/综述Key words
Thyroid Neoplasms/Iodothyronine Deiodinase/T3 Thyroid Hormone/Polymorphism,Single Nucleotide/Review引用本文复制引用
基金项目
浙江省基础公益研究基金资助项目(LGF22H070008)
浙江省医药卫生科技基金资助项目(2021KY850)
浙江省医药卫生科技基金资助项目(2022KY675)
浙江省杭州市医药卫生科技基金资助项目(OO20191087)
出版年
2024
国家科技期刊平台
NSTL
万方数据