Thyroid cancer (TC) is the most common endocrine malignancy. Although most patients have a favorable prognosis following standardized treatment,a subset experiences rapid disease progression and poor outcomes. Recent studies have identified N6-methyladenosine (m6A) methylation as the most prevalent RNA modification,which regulates RNA transcription,maturation,degradation,and stability,playing a role throughout the tumorigenesis process. Consequently,m6A methylation has been extensively studied in tumor treatment and prevention. Changes in m6A levels can lead to abnormal activation or inhibition of oncogenes or tumor suppressor genes in TC,thereby contributing to its initiation and progression. This review summarizes the concept of m6A methylation,the components and functions of its regulatory factors,its role in the development and progression of TC,and its implications for treatment and prognosis.
国家科技期刊平台
NSTL
万方数据
