m6A甲基化修饰在甲状腺癌发生发展中的作用研究进展
Role of m6A methylation modification in the occurrence and development of thyroid cancer:a review of research progress
田宏友 1程璐 1任艳 1郭琎祎 2马家骧 2宋爱琳1
作者信息
- 1. 兰州大学第二医院普通外科,甘肃兰州 730030;兰州大学第二临床医学院,甘肃兰州 730030
- 2. 兰州大学第二医院普通外科,甘肃兰州 730030
- 折叠
摘要
甲状腺癌(TC)是最常见的内分泌恶性肿瘤,尽管大多数患者经规范化治疗后预后良好,但部分患者病情进展迅速且预后不良.近年来研究发现,N6-甲基腺苷(m6A)甲基化是RNA最常见的修饰,参与调节RNA的转录、成熟、降解和稳定,贯穿于肿瘤的全过程,因此在肿瘤的治疗和预防中被广泛研究.m6A水平变化可引起TC中相关癌基因或抑癌基因的异常激活或抑制,从而参与TC的发生发展.笔者就m6A甲基化修饰的概念、调控因子的组成成分和功能、在TC发生发展中的作用及治疗和预后作用进行综述.
Abstract
Thyroid cancer (TC) is the most common endocrine malignancy. Although most patients have a favorable prognosis following standardized treatment,a subset experiences rapid disease progression and poor outcomes. Recent studies have identified N6-methyladenosine (m6A) methylation as the most prevalent RNA modification,which regulates RNA transcription,maturation,degradation,and stability,playing a role throughout the tumorigenesis process. Consequently,m6A methylation has been extensively studied in tumor treatment and prevention. Changes in m6A levels can lead to abnormal activation or inhibition of oncogenes or tumor suppressor genes in TC,thereby contributing to its initiation and progression. This review summarizes the concept of m6A methylation,the components and functions of its regulatory factors,its role in the development and progression of TC,and its implications for treatment and prognosis.
关键词
甲状腺肿瘤/N6-甲基腺嘌呤/预后/综述Key words
Thyroid Neoplasms/N6-Methyladenosine/Prognosis/Review引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据