Objective To understand the current progress of surgical treatment,radiotherapy,chemical drug therapy,endocrine therapy,targeted therapy,and immunotherapy of metaplastic breast cancer(MBC),so as to provide reference for the clinical therapy selection of MBC.Method The literature relevant to MBC therapy research in recent years was comprehensively reviewed.Results At present,the pathogenesis of MBC was not clear.The histopathology of MBC was more complex and the prognosis was poor.Compared with the invasive ductal carcinoma,the MBC patients had older age of onset,larger tumor diameter,faster growth and stronger invasiveness.The simple mastectomy was currently used in surgical treatment.The axillary lymph node involvement rate of MBC patients was lower,so the sentinel lymph node biopsy was widely used.The chemical drug therapy,endocrine therapy,and targeted therapy had limited effects on MBC patients.However,with its unique molecular expression by the genomic analysis of MBC and rise of precision medicine,targeted therapy and immunotherapy had become current research hotspots,providing potential therapeutic strategies for MBC patients.Conclusions Due to the complex histopathology and poor prognosis of MBC,and most research on MBC is retrospective studies,lacking sufficient prospective studies with sufficient sample size,so there is currently no clear consensus on the optimal treatment method for MBC.In order to better improve prognosis of MBC patients,further in-depth research on MBC histopathology,prospective studies with sufficient sample size,and development of targeted and effective therapeutic drugs are needed in the future.
metaplastic breast cancertreatment progresstargeted therapy
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维普
