首页|胰瘅通方联合金黄散从"瘀"论治非重症急性胰腺炎的回顾性队列研究

胰瘅通方联合金黄散从"瘀"论治非重症急性胰腺炎的回顾性队列研究

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目的 评价胰瘅通方保留灌肠联合金黄散外敷治疗非重症急性胰腺炎(non-severe acute pancreatitis,NSAP)的临床疗效.方法 采用回顾性队列研究设计,纳入2019年9月至2022年8月期间成都市第三人民医院收治的134例NSAP患者,所有患者接受西医常规治疗,根据是否接受胰瘅通方保留灌肠及金黄散外敷治疗将其分为观察组(n=66)与对照组(n=68),比较2组患者的不良临床转归事件发生率、治疗后病情严重程度评分、恢复排气排便时间、禁食禁水时间、治疗前后的中医证候积分、临床疗效及血液指标的变化.结果 观察组多器官功能衰竭(multiple organ dysfunction syndrome,MODS)、重症急性胰腺炎(severe acute pancreatitis,SAP)发生率均低于对照组(P＜0.05),观察组APACHE Ⅱ评分、BISAP评分和Ranson评分的治疗前后降低值均大于对照组(P＜0.05),观察组患者的恢复排气排便时间和禁食禁水时间均短于对照组(P＜0.05),观察组腹痛、腹胀、口干口苦的中医证候积分及各项血液指标的治疗前后降低值大于对照组(P＜0.05),观察组的中医证候积分总有效率(95.59％)高于对照组的83.33％(P＜0.05).结论 在西医常规治疗的基础上,胰瘅通方保留灌肠联合金黄散外敷治疗NSAP疗效佳.
Yidantong recipe combined with Jinhuang powder in treating non-severe acute pancreatitis from the perspective of"blood stasis":a retrospective cohort study
Objective To determine the effectiveness of Yidantong recipe retained enema combined with external application of Jinhuang powder on non-severe acute pancreatitis(NSAP).Methods A total of 134 patients with NSAP,admitted to the Third People's Hospital of Chengdu from September 2019 to August 2022 were included in this retrospective cohort study.All patients received routine Western medicine treatment,and they were divided into a observation group(n=66)and a control group(n=68)based on whether they underwent treatment of Yidantong recipe retained enema combined with external application of Jinhuang powder.The variables including incidence of adverse clinical outcome events,severity scores after treatment,the recovery time of flatus and bowel movement,duration of fasting food and water,scores of traditional Chinese medicine(TCM)syndromes and numerical value of blood indices before and after treatment,and the treatment effect of the two groups were statistically analyzed.Results Compared with that of the control group,the incidence of multiple organ dysfunction syndrome(MODS)and severe acute pancreatitis(SAP)of the observation group was lower(P＜0.05),and the reduction before and after treatment of APACHE Ⅱ score,BISAP score and Ranson score in the observation group was more than those in the control group(P＜0.05).Compared with that of the control group,the recovery time of flatus and bowel movement and duration of fasting food and water of the observation group was shorter(P＜0.05).The reduction before and after treatment of the scores of TCM syndromes(abdominal pain,abdominal distention,nausea and vomiting,dry mouth and bitter taste)and numerical value of blood amylase(AMY),alanine aminotransferase(ALT),alanine aminotransferase(AST)and C-reactive protein(CRP)in the observation group were more than those in the control group(P＜0.05).Compared with that of the control group(83.33％),the total effective rate of the scores of TCM syndromes(95.59％)of the observation group was higher(P＜0.05).Conclusion Yidantong recipe retained enema combined with external application of Jinhuang powder in the treatment of NSAP is effective by combining with routine Western medicine.

non-severe acute pancreatitisYidantong recipeJinhuang powder external application therapypromoting blood circulation and resolving blood stasisretrospective cohort study

邓杲、武鹏宇、覃海知、郗恒、王欣欣、陈敏

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西南交通大学附属医院&重庆医科大学附属成都第二临床医学院,成都市第三人民医院中医科(成都 610014)

西南交通大学附属医院&重庆医科大学附属成都第二临床医学院,成都市第三人民医院消化内科(成都 610014)

西南交通大学附属医院&重庆医科大学附属成都第二临床医学院,成都市第三人民医院药学部(成都 610014)

非重症急性胰腺炎 胰瘅通方 金黄散外敷疗法 活血化瘀 回顾性队列研究

四川省中医药管理局项目成都市科技局项目

2020LC00222021-YF05-00953-SN

2024

10.7507/1007-9424.202401049

中国普外基础与临床杂志
四川大学华西医院

中国普外基础与临床杂志

CSTPCD
影响因子：0.858
ISSN：1007-9424
年,卷(期)：2024.31(2)
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