Research progress on the relationship between cuproptosis and breast cancer
Objective To summarize the latest advances in copper and cuproptosis in the field of breast cancer,and to provide a reference for clinical treatment decisions.Method The literatures related to copper and cuproptosis in recent years were read and summarized,and the research progress on the role of copper in breast cancer,the application of cuproptosis in the diagnosis and treatment of breast cancer were reviewed.Results Cuproptosis was a novel form of programmed cell death,which occurred via direct binding of copper to lipoylated components of the tricarboxylic acid(TCA)cycle,this resulted in lipoylated protein aggregation and subsequent iron-sulfur cluster protein loss,leading to proteotoxic stress and ultimately cell death.Cuproptosis induced proliferation and migration of breast cancer cell,mediated personalized immunotherapy,and participated in endocrine and chemotherapeutic drug resistance.Conclusion Exploring the mechanism of cuproptosis provides potential applications for subsequent immunotherapy,endocrine therapy,and chemotherapy for breast cancer,leading to new effective strategies for patients.
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维普
