Research progress of YAP/TAZ in regulating drug resistance in cancer
Objective To elucidate the latest research progress of Yes-associated protein(YAP)/transcriptional coactivator with PDZ-binding motif(TAZ)in regulating tumor drug resistance.Method The relevant literature on YAP/TAZ in regulating tumor cell chemotherapy,immunotherapy,and targeted therapy resistance was reviewed and summarized in the databases such as PubMed,CNKI,and so on.Results The YAP/TAZ was involved in the resistance regulation of chemotherapy,immunotherapy,and targeted therapy in various human tumors.The YAP/TAZ could interact with various proteins to induce the occurrence of tumor resistance.The imbalance of YAP/TAZ signaling might lead to an important mechanism of tumor cell resistance.Conclusions There is a close relation between YAP/TAZ and tumor cell resistance.Studying the mechanism of YAP/TAZ regulating tumor resistance can provide new strategies and targets for addressing tumor resistance.
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