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药涂球囊在肾动脉型大动脉炎治疗中的应用

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目的 总结紫杉醇药物涂层球囊(drug coated balloon,DCB)在治疗肾动脉型大动脉炎中的安全性及有效性.方法 回顾性分析2019年1月至2023年8月期间笔者所在单位收治的3例(3条血管)肾动脉型大动脉炎患者的临床资料,3例患者均接受紫杉醇DCB球囊扩张.结果 3例患者介入治疗均获得成功,术后分别获访17、38和40个月.随访期间超声提示肾动脉血流均通畅.血清肌酐术前为53、64和55 μmol/L,术后第1天为43、70和59μmol/L,变动不明显;收缩压由术前的180、220和150 mmHg降至术后第1天的116、120和110 mmHg;肾动脉收缩期峰值流速由术前的350、377、293 cm/s降至术后第1天的120、135和94 cm/s.结论 初步结果表明,紫杉醇DCB治疗肾动脉型大动脉炎安全有效,但仍需大样本数据的临床研究进一步验证.
Application of drug coated balloon in treatment of Takayasu's arteritis of renal artery
Objective To study the clinical safety and effectiveness of paclitaxel-drug coated balloon(DCB)in treatment of Takayasu's arteritis(TA)of renal artery.Methods The retrospective analysis was made on the clinical data of the three patients with severe stenosis of renal artery,who were treated in our hospital from January 2019 to August 2023.The patients underwent paclitaxel-DCB dilation therapy.Results Successful treatment was accomplished in all the three patients.The patients were followed up for 17,38,and 40 months respectively,follow-up examination of ultrasound showed that the blood flow in renal artery was unobstructed.The serum creatinine level was changed from preoperative 53,64,55 μmol/L to 43,70,59 μmol/L on postoperative day 1.The systolic blood pressure was decreased from preoperative 180,220,150 mmHg to 116,120,110 mmHg on postoperative day 1.The peak systolic velocity of renal artery was reduced from preoperative 350,377,293 cm/s to 120,135,94 cm/s on postoperative day 1.Conclusion Paclitaxel-DCB is safe and effective for patients with renal artery stenosis of TA,but further researches with large sample are still needed.

Takayasu's arteritisdrug coated balloonrenal artery stenosis

刘一人、谷涌泉、郭连瑞

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首都医科大学宣武医院血管外科(北京 100053)

大动脉炎 药涂球囊 肾动脉狭窄

国家重点研发计划国家重点研发计划

2021YFC25005042022YFC3602404

2024

中国普外基础与临床杂志
四川大学华西医院

中国普外基础与临床杂志

CSTPCD
影响因子:0.858
ISSN:1007-9424
年,卷(期):2024.31(4)
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