Intestinal flora affects occurrence of hepatocellular carcinoma by regulating tumor microenvironment
Objective To review the role of intestinal flora on the tumor microenvironment and the effect ofboth on the development of hepatocellular carcinoma(HCC),with a view to providing new ideas on the causes of HCC development and progression.Method Relevant articles in the direction of intestinal flora and tumor microenvironment and HCC as well as the relationship between intestinal flora and tumor microenvironment in recent years were searched and summarized.Results The tumor microenvironment played an important role in the occurrence,development and postoperative recurrence of HCC.The intestinal flora,as one of the important regulators of tumor microenvironment,could induce HCC by affecting the tumor microenvironment in addition to interacting with the liver through the gut-liver axis.Conclusion Intestinal flora can influence to HCC by regulating the tumor microenvironment,and its specific mechanism of action still needs to be further investigated,which can be a new direction for HCC research.