奶酪或茶摄入与胃食管反流病的因果关联:两样本孟德尔随机化研究
Causal relationship of cheese and tea intake with gastroesophageal reflux disease:a two-sample Mendelian randomization study
陈鑫明 1赵平武 1何运胜 1黄坤 1黄朝林 1刘洋 1廖烽丸1
作者信息
- 1. 成都中医药大学附属绵阳医院普外科(四川绵阳 621000)
- 折叠
摘要
目的 分析奶酪或茶摄入与胃食管反流病(gastroesophageal reflux disease,GERD)发生风险之间是否具有因果关联.方法 采用两样本孟德尔随机化方法,将奶酪或茶摄入相关单核苷酸多态性(single nucleotide polymorphisms,SNPs)作为工具变量,采用MR Egger、加权中位数法(weighted median,WM)和逆方差加权法(inverse variance weighted,IVW)随机效应模型和IVW固定效应模型两种方法分析奶酪或茶摄入对GERD发生风险的因果效应,并以MR Egger法进行多效性分析和留一法进行敏感性分析来验证数据的可靠性.结果 奶酪摄入可减少GERD的发生[IVW随机效应模型β=-1.010,95％CI为(0.265,0.502),P＜0.05],茶摄入可导致GERD的发生[IVW随机效应模型β=0.288,95％CI为(1.062,1.673),P＜0.05].结论 奶酪摄入对减少GERD发生风险之间可能存在正向因果关系;茶摄入对增加GERD发生风险之间可能存在正向因果关系.
Abstract
Objective To analyze the causal relationship between the intake of cheese or tea and the risk of gastroesophageal reflux disease(GERD).Methods Using a two-sample Mendelian randomization approach,single nucleotide polymorphisms(SNPs)associated with milk or tea intake were used as instrumental variables.The causal effect of milk or tea intake on the risk of GERD was investigated using the MR Egger method,the weighted median method,the inverse-variance weighted(IVW)random-effects model,and the IVW fixed-effects model.Multivariable analysis was conducted using the MR Egger method,and leave-one-out sensitivity analysis was performed to validate the reliability of the data.Results Cheese intake could reduce the occurrence of GERD[IVW random-effects model β=-1.010,95％CI(0.265,0.502),P＜0.05],while tea intake could lead to the occurrence of GERD[IVW random-effects model β=0.288,95％CI(1.062,1.673),P＜0.05].Conclusion Cheese intake may have a positive causal relationship with reducing the risk of GERD occurrence,while tea intake may have a positive causal relationship with increasing the risk of GERD occurrence.
关键词
奶酪/茶/孟德尔随机化/胃食管反流病/因果推断Key words
cheese/tea/Mendelian randomization/gastroesophageal reflux disease/causal inference引用本文复制引用
出版年
2024
NETL
NSTL
万方数据