Advances in regulation of liver fibrosis through ionized free calcium/calmodulin/calmodulin-dependent protein kinase Ⅱ signaling pathway
Objective To summarize the role of ionized free calcium/calmodulin/calmodulin-dependent protein kinase Ⅱ(Ca2+/CaM/CaMK Ⅱ)signaling pathway in liver fibrosis so as to provide a theoretical basis for the treatment of liver fibrosis.Method The recent literature relevant research on the role of Ca2+/CaM/CaMK Ⅱ signaling pathway in the process of liver fibrosis both domestically and internationally was reviewed.Results The Ca2+/CaM/CaMK Ⅱ signaling pathway played a bidirectional regulatory role in the process of liver fibrosis,potentially facilitating the activation of hepatic stellate cells and triggering hepatocyte apoptosis through synergistic transforming growth factor-β1 and platelet-derived growth factor pathways.Conclusions At present,there is very little research on the role of Ca2+/CaM/CaMK Ⅱsignaling pathway in the process of liver fibrosis,and there is still insufficient understanding.Future research should focus on the mechanism of this signaling pathway in liver fibrosis,especially its upstream genes or downstream target proteins,which will aid to develop targeted and effective treatment strategies,achieve the reversal of liver fibrosis and even liver cirrhosis,and provide more effective treatment options for patients with liver fibrosis.
ionized free calciumcalmodulincalmodulin-dependent protein kinase Ⅱliver fibrosisextracellular matrix
NETL
NSTL
万方数据
