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肝棘球蚴病的新型检测手段

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全面概述了影像学、免疫学和分子生物学技术在肝棘球蚴病(又称"肝包虫病")检测中的应用.以超声、计算机断层扫描、磁共振成像和正电子发射断层扫描为代表的影像学技术,不仅提供了肝棘球蚴病病变的形态、位置、特征等重要信息,还可以与人工智能技术相结合,提高了疾病诊断能力,拓宽了影像技术应用场景,是肝棘球蚴病诊断、筛查和防控的重要手段.免疫学技术,如间接血凝试验、酶联免疫吸附试验、免疫印迹和化学发光免疫分析,通过检测特异性抗体,有助于诊断和鉴别诊断;分子生物学技术,如聚合酶链反应和高通量测序,以其高灵敏度和高特异性,为肝棘球蚴病的诊断和病原体鉴定提供了有力支持.在这三大技术基础上还出现了较多更灵敏、更特异、便捷和经济高效的特异性检测技术,为肝棘球蚴病的检测与防控提供了更多选择;同时结合不同检测技术的优势构建综合诊断模式,将有助于提高肝棘球蚴病的诊断效率.
Hepatic echinococcosis:Novel detection methods
We comprehensively outlined the application of imaging,immunology,and molecular biology techniques in the detection of hepatic echinococcosis(HE).Imaging techniques,represented by ultrasound,computed tomography,magnetic resonance imaging,and positron emission tomography,not only provided some critical information about the morphology,location,and characteristics of HE lesions,but also could be combined with artificial intelligence technologies to enhance the diagnostic capabilities and expand the application scenarios.These techniques were essential tools for the diagnosis,screening,and prevention of HE.Immunological techniques,such as the indirect hemagglutination assay,enzyme-linked immunosorbent assay,immunoblotting,and chemiluminescence immunoassay,aided in diagnosis and differential diagnosis by detecting the specific antibodies.Molecular biology techniques,such as polymerase chain reaction and high-throughput sequencing,provided a strong support for the diagnosis and pathogen identification of HE due to their high sensitivity and specificity.Based on these three major technologies,more sensitive,specific,convenient,and cost-effective detection techniques had emerged,offering more options for the detection and control of HE.Additionally,constructing comprehensive diagnostic models by combining the advantages of different detection technologies will aid to improve the diagnostic efficiency of HE.

hepatic echinococcosisliver hydatid diseasedetection techniquesdiagnosis

候圣祥、侯宗豪、邓满军、王海久、樊海宁

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青海大学附属医院肝胆胰外科(西宁 810001)

青海大学附属医院干细胞与再生医学实验室(西宁 810001)

青海省包虫病研究重点实验室(西宁 810001)

肝棘球蚴病 肝包虫病 检测技术 诊断

青海大学附属医院肝胆外科(包虫病)-国家临床重点专科建设项目青海科技厅2022年科技计划项目(青海省包虫病研究重点实验室)

青卫健办-125号

2024

中国普外基础与临床杂志
四川大学华西医院

中国普外基础与临床杂志

CSTPCD
影响因子:0.858
ISSN:1007-9424
年,卷(期):2024.31(10)