Advances in the study of gut microbiota and postoperative pain:mechanisms and prospects for clinical application
Objective To summarise the influencing factors of gut microbiota in the perioperative period and its regulatory mechanism in postoperative pain,with the aim of providing clinical reference for postoperative pain management.Method Relevant literatures on gut microbiota and postoperative pain in recent years were systematically reviewed and synthesised.Results Anaesthesia,preoperative mechanical bowel preparation,surgical stress,etc.could cause gut microbiota dysbiosis.Gut microbiota directly or indirectly modulated the excitability of primary sensory neurons through their derived metabolites and pathogen-associated molecular patterns and influenced the pain signalling process by activating immune cells to release cytokines.Conclusions Gut microbiota play an important role in the development and progression of postoperative pain.Future studies should further clarify its role in different types of postoperative pain and develop innovative therapeutic strategies based on the regulation of gut microbiota to improve the management of postoperative pain.
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