Objective To investigate the association between colorectal adenoma(CRA)and colorectal cancer(CRC),and to analyze the main pathogenesis of CRA,in order to identify and control the key factors of CRA and reduce the incidence of CRC.Method The studies on the mechanism of CRA in recent years were searched and summarized,focusing on the interaction of inflammation,genetic and epigenetic changes,gut microbiota and lipid metabolism,and their effects on the development of CRA.Results Inflammation,genetic and epigenetic changes,intestinal flora and lipid metabolism play an important roles in the occurrence and development of CRA.These factors had a significant impact on the formation and progress of CRA at different stages through complex interaction,and had potential application value in preventing CRC.Conclusions Many factors participate in the occurrence and development of CRA and plays an important role,which provide reference for future research and clinical intervention.
维普
万方数据