首页|结直肠腺瘤发生机制的研究进展

结直肠腺瘤发生机制的研究进展

扫码查看
目的 总结结直肠腺瘤(colorectal adenoma,CRA)与结直肠癌(colorectal cancer,CRC)的风险关联,分析其主要发生机制,以期识别和控制CRA的关键因素,降低CRC的发病率.方法 检索近年来国内外关于CRA发生机制的研究,重点分析炎症、遗传和表观遗传改变、肠道菌群和脂质代谢等因素的相互作用及其对CRA发展的影响,进行归纳总结.结果 炎症、遗传和表观遗传改变、肠道菌群和脂质代谢等因素在CRA发生和发展的过程中起重要作用.这些因素通过复杂的相互作用在不同阶段对CRA的形成和进展产生显著影响,并在预防CRC中具有潜在应用价值.结论 多种因素参与了 CRA的发生与发展并发挥了重要作用,这对未来的研究和临床干预提供了参考.
The research progress of colorectal adenomas mechanism
Objective To investigate the association between colorectal adenoma(CRA)and colorectal cancer(CRC),and to analyze the main pathogenesis of CRA,in order to identify and control the key factors of CRA and reduce the incidence of CRC.Method The studies on the mechanism of CRA in recent years were searched and summarized,focusing on the interaction of inflammation,genetic and epigenetic changes,gut microbiota and lipid metabolism,and their effects on the development of CRA.Results Inflammation,genetic and epigenetic changes,intestinal flora and lipid metabolism play an important roles in the occurrence and development of CRA.These factors had a significant impact on the formation and progress of CRA at different stages through complex interaction,and had potential application value in preventing CRC.Conclusions Many factors participate in the occurrence and development of CRA and plays an important role,which provide reference for future research and clinical intervention.

colorectal adenomaoccurrence mechanismrelevant factorreview

李兵、王士旭、刘艺行、王朝阳

展开 >

河南大学淮河医院普通外科(河南开封 475000)

结直肠腺瘤 发生机制 相关因素 综述

2024

中国普外基础与临床杂志
四川大学华西医院

中国普外基础与临床杂志

CSTPCD
影响因子:0.858
ISSN:1007-9424
年,卷(期):2024.31(12)