Therapeutic Effects of Ampelopsis Grossedentata on Nonalcoholic Fatty Liver Disease in Mice
Objective To investigate the therapeutic effects of ampelopsis grossedentataon nonalcoholic fatty liver and the possible mechanisms in mice.Methods A total of 48 male mice were randomly divided into four groups: control group, model group, positive control group, and ampelopsis grossedentata group.The model group received high fat diet.The positive control group received polyene phosphatidylcholine ( 150 mg/kg ) for 42 days from the 14th day.The ampelopsis grossedentata group were treated with ampelopsis grossedentata ( 300 mg/kg ) for 42 days from the 14th day.Morphological changes, liver indices, serum total cholesterol ( TC ), serum triglyceride ( TG ), alanine transaminase ( ALT ), aspartate transaminase ( AST ), liver TC, liver TG, and degrees of liver fatty degeneration were compared among the 4 groups.Results After treatment with ampelopsis grossedentata, serum levels of total cholesterol ( TC ), triglyceride ( TG ), alanine transaminase ( ALT ), aspartate transaminase ( AST ), liver TC, and liver TG were significantly decreased as compared with the nonalcoholic fatty liver model group ( P ＜0.05 ) and showed no significant differences when compared to the positive control group ( P ＞0.05 ).Histo-logical evaluation of mice liver showed dramatically decreased lipid accumulation in the ampelopsis grossedentata group.Conclusion Ampelopsis grossedentata exhibits therapeutic effect on nonalcoholic fatty liver in mice.
国家科技期刊平台
NSTL
万方数据
维普
