Cardiovascular disease(CVD)is one of the leading causes of death worldwide.In April 2022,the U.S.Preventive Services Task Force(USPSTF)updated and published recommendations on aspirin use to prevent CVD based on the latest evidence-based research results.The USPSTF recommends against initiating low-dose aspirin use for the primary prevention of CVD in adults aged 60 years and above.The decision to initiate low-dose aspirin use for the primary prevention of CVD in adults aged 40 to 59 years who have a 10%or greater 10-year CVD risk should be an individual one based on shared decision-making between clinicians and patients about the potential benefits and harms.This paper aims to interpret the latest recommendations in the context of China's actual situation,providing a reference on aspirin use to prevent CVD in China.