Background As a neurodegenerative disease,Alzheimer's disease(AD)has a high incidence rate and rapid development,which seriously affects the quality of life of patients.In recent years,research on music therapy intervention in AD has gradually increased,lacking effective systematic evaluation and analysis.Objective A meta-analysis was conducted on the intervention effects of music in the treatment of cognition,emotion,living ability and sleep disorders in AD patients.Methods Randomized controlled trials(RCT)on the intervention effect of music therapy methods on Alzheimer's patients were searched by computer in CNKI,Wanfang Data,VIP,Medline,Elsevier Science Direct,PubMed,and Embase from inception to February 2023,and the data was analyzed using RevMan 5.3 software.Results The study included 15 RCTs with a total of 1 077 patients.The results of Meta-analysis showed that the intervention effects of music therapy on cognitive function(MD=4.35,95％CI=1.64 to 7.05,Z=3.15,P=0.002),negative emotion(SMD=-0.71,95％CI=-1.26 to-0.15,Z=2.51,P=0.01),life ability(SMD=-0.91,95％CI=-1.55 to-0.27,Z=2.77,P=0.006)in the music therapy group was better than that of control group.There was no significant difference in sleep disorder intervention between the two groups(MD=-1.04,95％CI=-3.10 to 1.02,Z=0.99,P=0.32).Subgroup analysis showed that the music therapy groups with treatment period was<12 weeks(P=0.01),treatment duration<45 min/time(P=0.02),treatment frequency≥3 times/week(P<0.001),individual implementation method(P<0.001),individual+group implementation method(P=0.002),receiving music therapy as the intervention method(P<0.001)had better intervention effect on cognitive function than the control group;the music therapy groups with treatment period≥12 weeks(P=0.004),treatment frequency<3 times/week(P=0.01),implementation method of individual+group(P=0.02),intervention measure of receiving music therapy(P=0.002),intervention measure of active music therapy(P=0.002),had better intervention effect on negative emotions than the control group.Conclusion Music therapy can improve the cognitive function,mental state,and daily self activity of AD patients.However,due to the low quality of case studies included,more large-scale and high-quality evidence-based studies are still needed to verify.
Alzheimer diseaseMusic therapyTreatment outcomeCognitionEmotionsQuality of lifeMeta analysis
国家科技期刊平台
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