Background Acute pancreatitis(AP)is one of the common gastrointestinal emergencies,and the disease progression of moderately severe and severe AP is rapid.Early and accurate identification is crucial for effective intervention and prognosis assessment.there is still a lack of effective and simple predictive indicators.Objective To investigate the early dynamic changes and predictive value of the systemic inflammation response index(SIRI)in patients with AP.Methods A total of 221 AP patients who met the inclusion and exclusion criteria at the Department of Gastroenterology,Beijing Tiantan Hospital,Capital Medical University,were included as study subjects from August 2020 to March 2023.According to the revised 2012 Atlanta criteria,patients were categorized into mild group(MAP group,mild acute pancreatitis)and non-mild group(non-MAP group,including moderate severe and severe acute pancreatitis).The SIRI values(SIRI 0 h,SIRI 48 h)and C-reactive protein(CRP)levels(CRP 0 h,CRP 48 h)during admission and within 48 hours of admission for the patients were collected by reviewing cases.The receiver operating characteristic(ROC)curve was plotted,and the area under the curve(AUC)was calculated to analyze the predictive value of SIRI for non-MAP and compare it with CRP as a common clinical indicator of inflammation.Results A total of 221 AP patients were finally included,102 with MAP and 119 with non-MAP.SIRI 0 h and SIRI 48 h were higher in patients in the non-MAP group than in the MAP group(P<0.001).The ROC curve showed that the AUC for SIRI 0 h and SIRI 48 h in predicting non-MAP were 0.685(95%CI=0.615-0.756)and 0.753(95%CI=0.689-0.816),respectively,with no significant difference with CRP[0.607(95%CI=0.533-0.681)and 0.752(95%CI=0.687-0.817)]during the corresponding time intervals(Z=1.67,P=0.095;Z=0.02,P=0.981).The optimal cut-off value for SIRI 48h to predict non-MAP was 2.49,with sensitivity,specificity,positive predictive value,and negative predictive value of 81.51%,58.82%,69.78%,and 73.17%,respectively.Conclusion SIRI is an affordable and readily available test that can be used as an indicator for assessing the severity of early-stage AP.
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