首页|星形胶质细胞外囊泡在卒中后认知障碍中的研究进展

星形胶质细胞外囊泡在卒中后认知障碍中的研究进展

Research Progress of Astrocyte-derived Extracellular Vesicles in Post-stroke Cognitive Impairment

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卒中后认知障碍(PSCI)是卒中患者的常见并发症,以认知功能障碍为特征,直接影响患者生活质量.既往研究发现,星形胶质细胞在PSCI发病机制中发挥重要作用.此外,细胞外囊泡(EVs)已被公认为细胞间通讯中的重要递质,并通过携带和运输各种货物参与各种病理生理过程.星形胶质细胞外囊泡(ADEVs)可能与其他脑细胞进行交流,通过增强突触可塑性、调控神经炎症、调节血管生成和细胞自噬等过程改善PSCI.本综述阐明了ADEVs对PSCI发展的多方面影响,为研究PSCI的潜在机制提供新的策略,并进一步探讨ADEVs作为新型药物和生物标志物在诊断和治疗PSCI方面的潜在用途.
Post-stroke cognitive impairment,characterized by cognitive dysfunction,is a common complication of stroke and has a direct impact on the quality of life of ischemic stroke patients.Previous studies have found that astrocytes play an important role in the pathogenesis of PSCI.In addition,extracellular vesicles(EVs)have been recognized as an important medium for intercellular communication and are involved in various pathophysiological processes by carrying and transporting various cargoes.Astrocyte-derived extracellular vesicles(ADEVs)may communicate with other brain cells to improve PSCI by enhancing synaptic plasticity,modulating neuroinflammation,regulating angiogenesis and autophagy.This review clarifies the multiple effects of ADEVs on the development of PSCI,offers new strategies for studying the underlying mechanisms of PSCI,and further explores the potential uses of ADEVs as novel drugs and biomarkers in the diagnosis and treatment of PSCI.

StrokeCognition disordersAstrocyte-derived extracellular vesiclesSynaptic plasticityNeuroinflammation

肖雨倩、白艳杰、王岩、孙可心、万俊、陈淑颖、陈丽敏

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450000 河南省郑州市,河南中医药大学

450000 河南省郑州市,河南中医药大学第一附属医院

卒中 认知障碍 星形胶质细胞外囊泡 突触可塑性 神经炎症

河南省中医药科学研究专项重点课题河南省中医药传承与创新人才工程(仲景工程)中医药学科拔尖人才项目河南省科技攻关计划河南省卫生健康委国家中医临床研究基地科研专项河南省中医药拔尖人才培养专项

20-21ZY1009CZ0237-082221023105292022JDZX0052022ZYBJ07

2024

10.12114/j.issn.1007-9572.2023.0412

中国全科医学
中国医院协会

中国全科医学

CSTPCD北大核心
影响因子：2.04
ISSN：1007-9572
年,卷(期)：2024.27(20)
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