中国全科医学2024,Vol.27Issue(23) :2864-2868.DOI:10.12114/j.issn.1007-9572.2023.0574

基于线粒体功能及能量代谢探讨潘氏细胞与肠道干细胞的交互作用及中医药作用的可能靶点研究进展

Advances in Exploring the Interaction between Paneth Cells and Intestinal Stem Cells and Possible Targets for Traditional Chinese Medicine Based on Mitochondrial Function and Energy Metabolism

罗国樑 张馨丹 唐太春 朱焰 汪淑婷 陈敏
中国全科医学2024,Vol.27Issue(23) :2864-2868.DOI:10.12114/j.issn.1007-9572.2023.0574

基于线粒体功能及能量代谢探讨潘氏细胞与肠道干细胞的交互作用及中医药作用的可能靶点研究进展

Advances in Exploring the Interaction between Paneth Cells and Intestinal Stem Cells and Possible Targets for Traditional Chinese Medicine Based on Mitochondrial Function and Energy Metabolism

罗国樑 1张馨丹 1唐太春 1朱焰 1汪淑婷 1陈敏1
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作者信息

  • 1. 610072 四川省成都市,成都中医药大学附属医院/临床医学院
  • 折叠

摘要

肠道干细胞与潘氏细胞相互作用,共同维护肠道稳态及功能,肠道干细胞及潘氏细胞交互过程受到线粒体相关功能及能量转化的调控.中医药治疗肠道疾病的独特优势也体现在其对于线粒体及能量代谢的作用方面.本文探讨线粒体功能及能量代谢对肠道干细胞、潘氏细胞交互的影响,并探索中医药治疗肠道疾病中与线粒体相关的可能靶点,总结中医药对线粒体及能量代谢的调节作用,进而恢复肠道稳态,缓解疾病.以期为基于线粒体研究肠道干细胞、潘氏细胞的中医药治疗相关研究提供一定的参考及理论依据.

Abstract

Intestinal stem cells and Paneth cells interact with each other to maintain intestinal homeostasis and function,the interaction between intestinal stem cells and Paneth cells is regulated by mitochondria-related functions and energy conversion.The unique advantages of traditional Chinese medicine(TCM)in the treatment of intestinal diseases are also reflected in its effects on mitochondria and energy metabolism.This paper explores the influence of mitochondrial function and energy metabolism on the interaction between intestinal stem cells and Paneth cells,as well as the possible targets related to mitochondria in the treatment of intestinal diseases by TCM,summarizes the regulatory effects of TCM on mitochondria and energy metabolism,thereby restoring intestinal homeostasis and alleviating disease,with an aim to provide reference and theoretical basis for the research related to the TCM treatment of intestinal stem cells and Paneth cells based on mitochondria.

关键词

肠道干细胞/潘氏细胞/线粒体/能量代谢/中医药

Key words

Intestinal stem cells/Paneth cells/Mitochondria/Energy metabolism/Traditional Chinese Medicine

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基金项目

国家自然科学基金(82274529)

科研能力提升"百人计划"(20-B05)

出版年

2024
中国全科医学
中国医院协会

中国全科医学

CSTPCD北大核心
影响因子:2.04
ISSN:1007-9572
参考文献量37
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