Diabetic foot ulcer(DFU)is usually accompanied by varying degrees of peripheral neuropathy and vasculopathy.It is a difficult-to-heal wound.The delayed healing process is mainly due to new blood vessel regeneration disorder,persistent wound inflammation,wound re-epithelialization disorder and abnormal fibroblast proliferation.Exosomal miRNA,as an important medium for intercellular communication,is involved in a variety of biological processes and can regulate the transcription and translation of various target genes affecting DFU healing.This paper aims to briefly review the role of exosomal miRNAs in the regulation of neointimal regeneration,inflammatory response,wound re-epithelialization function,and fibroblast proliferation function in the repair of DFU,to provide new ideas for the treatment of DFU.
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