摘要
背景 目前关于中国 10～24 岁年轻人(简称年轻人)偏头痛疾病负担的系统研究有限.目的 基于全球疾病负担数据库(GBD),探究 2021 年中国年轻人偏头痛疾病负担情况,并分析不同年龄、性别和时间模式下的变化情况.方法 从 2021 年GBD(简称GBD 2021)中提取 1990-2021 年偏头痛相关数据,选取患病率、发病率、伤残调整寿命年(DALYs)率作为评估偏头痛疾病负担的指标.采用变化率及年均变化百分比(EAPC)评估 1990-2021 年年轻人偏头痛疾病负担变化趋势.结果 2021 年,中国年轻人偏头痛患病例数 2 763.8 万人(95%UI=2 145.5～3 505.2)、发病例数 349.8 万人(95%UI=273.5～427.5)、DALYs为 103.0 万人年(95%UI=9.2～249.6),均约占全球年轻人偏头痛总数的 1/11,占中等社会发展指数(Middle SDI)地区年轻人偏头痛总数的30%左右.但患病率、发病率、DALYs率均低于全球平均水平和Middle SDI地区的水平;中国年轻人偏头痛患病率为 11 809.0/10万,低于全球平均水平 16 108.1/10万,同时也低于Middle SDI地区的 16 455.8/10万.1990-2021年,中国年轻人偏头痛患病率、发病率和DALYs率均呈上升趋势,患病率从1990年的11 556.5(95%UI=9 120.2～14 491.3)/10万上升到2021年的11 809.0(95%UI=9 167.3～14 976.8)/10 万,EAPC为 0.28(95%CI=0.15～0.40),发病率从 1990 年的 1 379.5(95%UI=1 075.3～1 708.2)/10 万上升到 2021 年的 1 494.6(95%UI=1 168.5～1 826.5)/10 万,EAPC为 0.17(95%CI=0.10～0.24),DALYs率从1990 年的 430.9(95%UI=42.0～1 033.0)/10 万上升到 2021 年的 440.2(95%UI=39.4～1 066.6)/10 万,EAPC为 0.29(95%CI=0.16～0.42).与 1990 年相比,2021 年中国年轻人偏头痛患病例数、发病例数和DALYs均减少约 1/3.此外,中国年轻人偏头痛负担存在年龄和性别差异,其中10～14岁年龄组患病率、发病率和DALYs率上升趋势较明显,EAPC分别为 0.28(95%CI=0.24～0.33)、0.27(95%CI=0.22～0.33)和 0.29(95%CI=0.25～0.34).中国年轻人女性偏头痛负担高于男性.2021 年中国女性在 10～14 岁、15～19 岁、20～24 岁以及整个 10～24 岁年龄段中,女性的患病率、发病率和DALYs率约是男性的 1.7 倍.结论 整体来说,2021 年较 1990 年中国年轻人偏头痛患病例数、发病例数和DALYs均减少约 1/3.但从过去 32 年的整体趋势看,患病率、发病率和DALYs率均呈上升趋势.性别方面,各年龄段女性年轻人偏头痛负担均高于男性.年龄方面,尽管目前中国 10～14 岁年龄段的年轻人偏头痛负担相对较轻,但其疾病负担增长速度最快.
Abstract
Background At present,there are limited systematic studies on the burden of migraine disease in young people aged 10～24 years in China.Objective Analyzing the current burden of migraine among Chinese young people in 2021,and exploring the changing trends in the burden of migraine from 1990 to 2021 by age,gender,and temporal patterns.Methods From the Global Burden of Disease(GBD)database,migraine data from 1990 to 2021 were extracted,with prevalence,incidence,and disability-adjusted life years(DALYs)selected as indicators to assess the burden of migraine.Assess the trends in the changes of prevalence rate,incidence rate,and DALYs rate cases in 2021 compared to 1990 by using percentage changes.Establishing the estimated annual percentage change(EAPC)model to assess the trends in prevalence,incidence,and DALYs rates over the past 32 years.Results In 2021,the Chinese prevalence,incidence,and DALYs cases of migraine among young people were 27.638 million,3.498 million,and 1.03 million person-years,respectively,which respectively account for 1/11 of the global cases and 30%of the middle socio-demographic index(Middle SDI)regions.However,the prevalence rate,incidence rate,and DALYs rate in China were all lower than those in the global and Middle SDI regions.Specifically,the prevalence rate among young people in China was 11 809.0 per 100 000 population,which was lower than the global rate of 16 108.1 per 100 000 and the rate in Middle SDI regions of 16 455.8 per 100 000 population.From 1990 to 2021,the prevalence rate,incidence rate,and DALYs rate of migraine among young people in China all showed an increasing trend.The prevalence rate rose from 11 556.5(95%UI=9 120.2-14 491.3)per 100 000 population in 1990 to 11 809.0(95%UI=9 167.3-14 976.8)per 100 000 population in 2021,with an EAPC of 0.28(95%CI=0.15-0.40).The incidence rate increased from 1 379.5(95%UI=1 075.3-1 708.2)per 100 000 population in 1990 to 1 494.6(95%UI=1 168.5-1 826.5)per 100 000 population in 2021,with an EAPC of 0.17(95%CI=0.10-0.24).The DALYs rate rose from 430.9(95%UI=42.0-1 033.0)per 100 000 population in 1990 to 440.2(95%UI=39.4-1 066.6)per 100 000 population in 2021,with an EAPC of 0.29(95%CI=0.16-0.42).Compared to 1990,the number of prevalent cases,incident cases,and DALYs cases of migraine among young people in China decreased by approximately one-third in 2021.Additionally,there were significant age and gender differences in the migraine burden among young people in China.A particularly noticeable upward trend in prevalence,incidence,and DALYs rates was observed in the 10-14 age group,with EAPCs of 0.28(95%CI=0.24-0.33),0.27(95%CI=0.22-0.33),and 0.29(95%CI=0.25-0.34).The migraine burden among young women in China was higher than that in men.In 2021,women aged 10-14,15-19,20-24,and the overall 10-24 age group had prevalence,incidence,and DALYs rates approximately 1.7 times higher than those of men.Conclusion From 1990 to 2021,the prevalent cases,incidenct cases,and DALYs cases of migraine among Chinese young people have all shown an increasing trend.Among young people in each age group,the migraine burden is higher in females than in males.Based on age distribution,despite the relatively low burden of migraine among young people aged 10-14 in China,this age group has experienced the fastest growth rate in disease burden.These characteristics indicate the need for targeted intervention measures for adolescent migraine issues in China.
维普
万方数据