Blood vitamin characteristics and their correlation with severity in patients with metabolic-related fatty liver disease
Objective To explore the characteristics of blood vitamins A,B2,B6,B12,D,E,K1,K2 and folic acid and their correlation with severity in patients with metabolic-related fatty liver disease(MAFLD).Methods From September to December 2022,a total of 473 cases of residents were recruited through community MAFLD screening activities and their health information was obtained through questionnaire survey and physical examination.The severity of hepatic steatosis was determined with FibroScan,and vitamin concentrations were determined with liquid chromatography-tandem mass spectrometry.Two independent samples't-tests were used to assess the differences between the two groups,and univariate chi-square tests and multivariate logistic regression analysis were used to explore the related factors of MAFLD.Results Of the 473 inhabitants,195(41.23%,195/473)met the diagnostic criteria for MAFLD,including mild 43(22.05%,43/195)cases of fatty liver,88(45.13%,88/195)cases of moderate fatty liver,and 64(32.82%,64/195)cases of severe fatty liver.Using healthy residents collected during the same period as controls,the overall mean of vitamins A,E,K1,and K2 in the MAFLD group was higher than that of the healthy group,with a statistical difference(P<0.05).Furthermore,the concentrations of vitamins A,E,K1 and K2 increased with the severity of fatty liver[R=0.149,P=0.004;R=0.245,P<0.001;R=0.110,P=0.032;R=0.129,P= 0.012].There were statistically significant differences(P<0.05)in the blood levels of vitamin A and E between patients with moderate or severe fatty liver and the healthy population.The blood vitamins K1 and K2 in severe fatty liver patients were also different from those of healthy people(P<0.05).However,there was no significance between folic acid,vitamin D,B2,B6,B12,and MAFLD(P>0.05).Through univariate chi-square analysis and multivariate logistic regression analysis,it was found that male[Wald=5.789,P=0.034,OR=1.598(1.037-2.463)]and vitamin E≥8.13 μg/mL[Wald=14.632,P<0.001,OR=2.378(1.522-3.674)]were risk factors for moderate and severe MAFLD.Conclusions The concentrations of vitamin A,E,and K in the blood are increased in patients with MAFLD compared to the healthy population,and they are positively correlated with the severity of MAFLD.ale gender and high levels of vitamin E may be related to moderate to severe MAFLD.
NETL
NSTL
万方数据
维普
