Objective To explore the clinical characteristics and drug resistance of Elizabethkingia meningoseptica(EM)nosocomial infection,so as to provide evidence for prevention of EM nosocomial infection and guiding the rational use of antibiotics.Methods A retrospective study was conducted of 67 patients with EM infection in a tertiary hospital from January 2021 to December 2022.The infective characteristics and drug resistance were analyzed.Results The cohort of 67 EM-infected patients was predominantly males aged≥60 years,with the most frequent source being the first district of the intensive care unit(ICU),followed by the respiratory medicine and emergency department(19.40%,13/67).The specimens were mainly isolated from respiratory tract(86.57%,58/67),of which sputum accounted for 49.25%(33/67),and alveolar lavage fluid accounted for 37.31%(25/67).The majority of EM infections occurred in patients with pre-existing respiratory conditions(49.25%,33/67),who generally experienced prolonged hospital stays and underwent invasive procedures,such as mechanical ventilation 94.03%(63/67),urinary catheterization(95.52%,64/67),and central venous catheterization(97.01%,65/67).Post-treatment,the improved rate of the 67 patients was 40.30%(27/67).Susceptibility testing demonstrated a high resistance rate of EM to cefoperazone-sulbactam,98.39%(61/62),contrasted by significant susceptibility to compound trimethoprim-sulfamethoxazole(TMP-SMX)/cotrimoxazole,doxycycline,minocycline,and piperacillin-tazobactam,with susceptibility rates exceeding 90%.Conclusions The patients infected with EM were almost elderly men with certain underlying diseases,experienced prolonged hospital stays,and had a history of invasive operations.The specimens of EM were mainly from Intensive Care Unit and isolated from respiratory tract.The strain showed high resistance to cefoperazone-sulbactam,whereas it remained highly susceptible to cotrimoxazole,doxycycline,minocycline and piperacillin-tazobactam,which may be considered as first-line treatment options.
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