目的 研究深圳市龙岗区猴痘疫情的临床及流行病学基本特征,并综合进行分析讨论,为猴痘疫情防控提供参考.方法 选取2023年6月龙岗区医疗机构发现的16例猴痘病例开展流行病学调查,分析病例的三间分布、高危暴露特点(接触对象、方式、地点等)、发病特点及就诊情况,并结合实际情况以及遇到的问题进行疫情防控相关讨论.结果 病例均为未婚青年男性、男男性行为人群(men who have sex with men,MSM);疾病通过同性接触的人传人方式传播,感染来源为非固定性伴,暴露地点较为隐匿,潜伏期平均值为8.42 d;病例发现方式以主动就诊为主,为68.78%(11/16);首发症状以发热为主,为56.25%(9/16);主要症状为皮疹和发热,分别为100%和68.75%(11/16);发热到出疹的时间以0～3 d为主,占比90.91%(10/11);出疹部位涉及全身多个不同部位,出疹无特殊顺序;发病到就诊与发病到被发现的时间间隔相近,分别为5.91 d和5.94 d;病例多为HIV感染者,为68.75%(11/16).结论 猴痘疫情在MSM人群中流行,通过男男性接触经人传人方式传播,但因性伴不固定且暴露地点隐匿导致溯源较难,潜伏期平均为8.42 d;症状上以发热、皮疹为主,发病至就医时间较长,症状较轻,初次就医存在漏诊现象,病例无法及时发现并管控;同时,疫情调查处置防控存在一定难度.
Epidemiological investigation on the of 16 cases of monkeypox
Objective To study the clinical and epidemiological characteristics of the monkeypox epidemic in Longgang District,Shenzhen,and conduct a comprehensive analysis and discussion to provide a reference for monkeypox epidemic prevention and control.Methods An epidemiological investigation was conducted on 16 monkeypox cases found in the medical institutions of Longgang District on June 2023.The distribution of cases,high-risk exposure characteristics(contact objects,methods,locations,etc.),incidence characteristics,and medical treatment situation were analyzed.Relevant discussions on epidemic prevention and control were further conducted in light of the actual situation and the problems encountered.Results The cases were all unmarried young men and men who have sex with men(MSM)population.The disease was transmitted from person to person through same-sex contact,with non-fixed sexual partners as the source of infection and exposure locations being relatively concealed,and the average incubation period was 8.42 days.Most cases were discovered through active seeking medical attention,accounting for 68.78%(11/16).Fever was the primary initial symptom accounting for 56.25%(9/16),with the main symptoms being a rash and fever,at 100% and 68.75%(11/16),respectively.Time from fever to rash onset was mainly 0-3 days,accounting for 90.91%(10/11).The eruption site involveed multiple different parts of the body,and there was no special order of eruption.The time interval from onset to seeking medical attention and from onset to discovery was similar,with 5.91 days and 5.94 days respectively.The majority of cases were HIV infected,accounting for 68.75%(11/16).Conclusions The monkeypox epidemic is prevalent in MSM populations and is transmitted through male to male contact through human transmission.However,due to unstable sexual partners and concealed exposure locations,tracing the source is difficult,with an average incubation period of 8.42 days.The symptoms are mainly fever and rash,with a long time from onset to medical treatment.The initial manifestations are mild,leading to missed diagnoses on the first visit,resulting in difficulty in timely discovery and prevention of further cases.At the same time,investigating and handling the epidemic are challenging,making the prevention and control of the outbreak a difficult task.
Monkeypoxepidemiological characteristicsclinical symptom characteristicsepidemic prevention and control
NETL
NSTL
万方数据
维普
