Negative association between composite dietary antioxidant index and excess heart age
Objective To investigate the relationship between the composite dietary antioxidant index(CDAI)and excess heart age(EHA),offering theoretical insights into the nutritional prevention of cardiovascular disease(CVD).Methods Data for this cross-sectional analysis was derived from the National Health and Nutrition Examination Survey(NHANES)from 2007 to 2020,which included 16 442 participants aged 30 to 74 years without a history of CVD.The heart age was estimated using the Framingham risk score function,and EHA was subsequently calculated.The CDAI was formulated based on intake levels of vitamins A,C,E,zinc,selenium,and carotenoids to represent the overall level of antioxidants.The association between CDAI and EHA was evaluated using multivariate linear regression,multivariate logistic regression,and restricted cubic splines(RCS).Results Multiple regression analysis indicated that CDAI was negatively correlated with both EHA(β=-0.07,95％CI:-0.14 to-0.01)and high CVD risk(defined as EHA≥10 years)(OR=0.98,95％CI:0.96 to 1.00),with RCS analysis suggesting that this relationship is a nonlinear and inverse L-shaped.In the female subgroup,significant negative,nonlinear associations were observed between CDAI and both EHA(β=-0.10,95％CI:-0.12 to 0.00)and high CVD risk(OR=0.97,95％CI:0.94 to 0.99).Conversely,in males,these correlations did not reach statistical significance.Conclusions Our findings suggest that individuals with higher CDAI compliance had a lower risk of CVD,and this negative correlation was gender specific.This discovery offers new theoretical guidance for the nutritional prevention of CVD,underlining the necessity for more comprehensive clinical and foundational research to further explore this association.
NETL
NSTL
万方数据
