The current situation of willingness to receive prophylactic treatment among students with latent tuberculosis infection and its influencing factors in Jiangsu Province
Objective To assess the willingness of students with latent tuberculosis infection(LTBI)in Jiangsu Province to undergo preventive treatment and identify factors influencing their decision,aiming to provide insights for tuberculosis prevention and control strategies in school.Methods The physical examination information of tuberculosis latent infection cases was collected from screenings of new school enrollment and contacts of tuberculosis patients in 6 cities of Jiangsu Province from December 2022 to December 2023.Data on past medical history and understanding of preventive treatment were gathered through an online questionnaire survey on the website of Juanxing,and the influencing factors related to the willingness to take preventive medication were analyzed by logistic regression analysis model.Results In December 2022 to December 2023,a total of 13 school tuberculosis outbreaks occurred in 6 cities,and 1 661 contacts were screened,among which 162 cases met the criteria for prophylactic medication,96 cases were included in the study by filling in the questionnaire.A total of 22 600 new students from 56 schools participated in the TB screening upon enrollment,of which 358 tested positive for the tuberculin skin test alone,meeting the criteria for preventive medication,and 251 of them completed the willingness survey.Finally,347 students who met the criteria for preventive treatment were included in the study,with 164 expressing to accept preventive treatment representing a treatment acceptance rate of 47.3％.The results of multivariate analysis showed that university(OR=17.950,95％CI:3.078-104.686,P=0.001)and contact with the source of school tuberculosis epidemic(OR=19.542,95％CI:6.289-60.726,P＜0.001)were associated with increased willingness to receive preventive treatment,while unclear whether to pay for the drugs themselves(0R=0.349,95％CI:0.133-0.916,P=0.032)was associated with decreased willingness to receive preventive treatment.Compared with Huai'an City,the willingness to receive preventive treatment was significantly lower among students from Nantong City(OR=0.005,95％CI:0.000-0.063,P＜0.001),Nanjing City(OR=0.022,95％CI:0.003-0.703,P＜0.001)and Lianyungang City(OR=0.074,95％CI:0.008-0.703,P=0.023).Conclusions The acceptance rate of preventive treatment among LTBI students in Jiangsu Province is not high and is affected by multiple factors.Health education and medication mobilization for preventive medication are essential.
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