Progress in the research of pre-erythrocytic malaria vaccines
Malaria is a significant global infectious disease that once wreaked havoc in China as well.In recent years,the global malaria control situation has stagnated,and China is also facing a huge threat of imported malaria.So,effective malaria vaccines are urgently needed as a supplementary strategy to the existing prevention and control measures.Compared to vaccines targeting the erythrocytic stage and those designed to block transmission,vaccines aimed at preventing infection during the pre-erythrocytic stage have attracted more attention and have made a series of progress in recent years.At present,the only two malaria vaccines recommended by the World Health Organization(WHO)are pre-erythrocytic vaccines.In this paper,the current situation and trend of pre-erythrocytic malaria vaccine research and development are reviewed,intending to provide a reference for the research,development,and application of malaria vaccines in the future.
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