Effects of air pollution on lung function and nasal inflammatory factors in healthy migrant college students
Objective To understand the current situation of lung function and nasal inflammation of students from different places of origin,and to explore the possible relationship between air pollutants and lung function and inflammatory factors of healthy college students.Methods A self-designed questionnaire was used to investigate 253 healthy college students,including their basic personal information,the origin of students,and their living environment,then their lung functions were tested,including forced vital capacity(FVC),forced expiratory volume in 1 second(FEV1),and peak expiratory flow(PEF).Furthermore,according to the air quality of the region of origin,60 students from areas with good air quality and 30 students from areas with poor air quality were selected.Nasal inflammatory factors(IL-6 and TNF-α levels)were detected before(July 12,2019)and after summer vacation(August 27,2019)to analyze the impact factors on lung function in healthy college students and the level of nasal inflammatory markers after short-term differential exposure to air pollutants.Results The univariate analysis of the questionnaire survey showed that the lung function of healthy college students was influenced by urban-rural distribution,air quality of students'origin,and height.Multivariate analysis found that compared with urban healthy college students,the FVC and FEV1 of rural students increased by 0.346 L and 0.322 L respectively(P＜0.05).In addition,for each decrease in the grade of air quality of students'origin,FEV1 and PEF decreased by 0.193 L and 0.687 Us respectively(P＜0.05).After differential exposure to air pollutants during the holiday,healthy college students from areas with poor air quality had higher levels of the nasal mucous membrane inflammatory marker TNF-α than those from areas with good air quality(P＜0.05).Conclusions The lung function of healthy college students is affected by urban-rural distribution and the air quality of their region of origin,and the short-term differential exposure to air pollutants leads to changes of nasal inflammatory factors in young healthy individuals.
Lung functioninflammatory factorsair qualityhealthy college students
NETL
NSTL
万方数据
