Immunological effects of antiviral therapy and its influencing factors in HIV/AIDS patients in Hainan
Objective To investigate the status of participation in highly active antiretroviral therapy(HAART)among individuals infected with human immunodeficiency virus(HIV)/patients with acquired immunodeficiency syndrome(AIDS)(hereinafter referred to as HIV/AIDS)in Hainan province,and to analyze the immunological outcomes and their influencing factors following treatment.Methods In this study,HIV/AIDS patients treated in Hainan Province until 2022 from the antiretroviral treatment were selected from the antiviral treatment submodule of the China Disease Prevention and Control Information System.According to the inclusion and exclusion criteria,a total of 3 150 HIV/AIDS patients were enrolled.Logistic regression analysis was used to analyze factors affecting the immunological effect of antiretroviral therapy.Results Of the 3 150 subjects,2 906 achieved immunological success,accounting for 92.2%.The M(P25,P75)CD4+T lymphocyte count after treatment was 491(351,656)cells/μL.There were significant differences in the increase in CD4+T lymphocyte counts after treatment compared to baseline across different CD4+T levels(P＜0.001).Multifactorial logistic regression analysis showed that being divorced or widowed(OR=0.50,95%CI:0.31-0.79),age≥60 years at the onset of treatment(OR=0.51,95%CI:0.29-0.90),the interval from diagnosis to treatment of 1 to＜12 months(OR=0.55,95%CI:0.40-0.77),12 to＜60 months(OR=0.53,95%CI:0.34-0.80),and≥60 months(OR=0.41,95%CI:0.23-0.75),as well as a CD4+T cell count of 300 to＜400 cells/μL(OR=0.36,95%CI:0.22-0.58)and 400 to＜500 cells/μL(OR=0.30,95%CI:0.18-0.49)were negative correlation with immunological success(P＜0.05).On the other hand,homosexual transmission(OR=3.46,95%CI:2.03-5.90),heterosexual transmission(OR=1.91,95%CI:1.14-3.19),other/unknown transmission(OR=3.13,95%CI:1.50-6.53),treatment years count 2 to＜4 years(OR=1.71,95%CI:1.13-2.58),4 to＜6 years(OR=2.86,95%CI:1.81-4.51),and≥6 years(OR=2.21,95%CI:1.47-3.32)were positive correlation with immunological success(P＜0.05).Conclusions The highly active antiretroviral therapy has achieved good immunological effects among patients with HIV/AIDS in Hainan Province.It is essential to expand HIV monitoring and detection,to diagnose and treat at an early stage,and to continue strengthening medication compliance education to further improve the immunological effects of treatment.
Acquired immune deficiency syndromehighly active antiretroviral therapyimmunological effectinfluencing factor
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