Pathogen infection-induced trained immunity and its research progress
It has long been thought that immune memory is an exclusive hallmark of adaptive immunity,but recent studies have shown that innate immunity also has characteristics similar to immune memory.Innate immune cells,upon being stimulated by pathogens such as lipopolysaccharide(LPS)and β-glucan,can develop a form of immune memory.Upon a secondary encounter with the stimulus,these innate immune cells can produce a stronger immune response,providing nonspecific protection.This immune phenomenon is termed"trained immunity".The mechanism of trained immunity mainly involves the epigenetic reprogramming and metabolic reprogramming of innate immune cells and the interaction between them.This article reviews the main research progress and mechanism of pathogen infection-induced trained immunity.
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