病原体感染诱导的训练免疫及其研究进展
Pathogen infection-induced trained immunity and its research progress
叶升玉 1潘卫庆1
作者信息
- 1. 中国人民解放军海军军医大学海军医学系热带病学教研室,上海 200433
- 折叠
摘要
长期以来认为,免疫记忆是属于适应性免疫的主要特征,但近来研究显示,固有免疫也具有类似免疫记忆特征.固有免疫细胞在受到病原体如脂多糖(lipopolysaccharide,LPS)和β-葡聚糖(β-glucan)等免疫原刺激后能产生免疫记忆,当二次遭遇刺激时,固有免疫细胞能产生更强的免疫应答,发挥非特异性保护作用,此免疫现象称为"训练免疫".训练免疫产生的机制主要涉及固有免疫细胞表观遗传重编程(epigenetic reprogramming)和代谢重编程(metabolic reprogramming)及其两者间的交互作用.本文综述了病原体感染介导的训练免疫的主要研究进展及其机制.
Abstract
It has long been thought that immune memory is an exclusive hallmark of adaptive immunity,but recent studies have shown that innate immunity also has characteristics similar to immune memory.Innate immune cells,upon being stimulated by pathogens such as lipopolysaccharide(LPS)and β-glucan,can develop a form of immune memory.Upon a secondary encounter with the stimulus,these innate immune cells can produce a stronger immune response,providing nonspecific protection.This immune phenomenon is termed"trained immunity".The mechanism of trained immunity mainly involves the epigenetic reprogramming and metabolic reprogramming of innate immune cells and the interaction between them.This article reviews the main research progress and mechanism of pathogen infection-induced trained immunity.
关键词
训练免疫/病原体/感染/表观遗传重编程/代谢重编程Key words
Trained immunity/pathogen/infection/epigenetic reprogramming/metabolic reprogramming引用本文复制引用
出版年
2024
NETL
NSTL
万方数据