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儿童呼吸道病毒感染相关神经系统并发症

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儿童呼吸道病毒感染虽然主要引起呼吸系统疾病,但重症呼吸道病毒感染与神经系统感染、炎症或功能障碍密切相关.人类呼吸道合胞病毒、流感病毒、冠状病毒和人偏肺病毒等常见呼吸道病毒均可导致严重的神经系统并发症,如脑炎、急性播散性脑脊髓炎、小脑炎、格林巴利综合征、急性弛缓性脊髓炎、坏死性脑病等,危及生命.新型冠状病毒疫情的暴发使重症患儿神经系统并发症的发生率和病死率不断攀升.本文探讨儿童呼吸道病毒感染的神经侵袭机制及神经系统表现,旨在提高医护人员对儿童呼吸道病毒感染相关神经系统并发症的早期识别,以减少并发症对儿童健康的危害.
Neurological complications associated with respiratory virus infections in children
Although respiratory tract viral infections in children mainly cause respiratory diseases,severe respiratory viral infections are closely associated with infections,inflammation,or dysfunction of the nervous system.Common respiratory viruses such as human respiratory syncytial virus,influenza virus,coronaviruses,and human metapneumovirus can lead to severe neurological complications including encephalitis,acute disseminated encephalomyelitis,cerebellitis,Guillain-Barré syndrome,acute flaccid myelitis,and necrotizing encephalopathy,posing a threat to life.The outbreak of the SARS-CoV-2 epidemic has continuously increased the incidence and mortality of neurological complications in critically ill children.Therefore,this article will discuss the neuroinvasive mechanisms and neurological manifestations of respiratory viral infections in children,aiming to enhance early recognition of neurological complications related to respiratory viral infections in children by healthcare professionals and to minimize the harm of complications to children's health.

Respiratory virusespathogenesisSARS-CoV-2influenza virushuman respiratory syncytial virus

张铮铮、陈伟明

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复旦大学附属儿科医院,上海 201102

呼吸道病毒 发病机制 新型冠状病毒 流感病毒 呼吸道合胞病毒

国家重点研发计划项目国家重点研发计划项目上海市卫生健康系统重点扶持学科项目

2021YFC27018002021YFC27018012023ZDFC0103

2024

中国热带医学
中华预防医学会,海南疾病预防控制中心

中国热带医学

CSTPCD北大核心
影响因子:0.722
ISSN:1009-9727
年,卷(期):2024.24(7)
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