中国人民解放军军医大学学报(英文版)2013，Vol.28Issue(5) ：273-280.

The effect of spleen on the change of Treg cells during mouse pregnancy

GAO Qing LI Mu ZHANG Shu ZHOU Rui WU Jinfang LI Zongfang
中国人民解放军军医大学学报(英文版)2013，Vol.28Issue(5) ：273-280.
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The effect of spleen on the change of Treg cells during mouse pregnancy

GAO Qing 1LI Mu 1ZHANG Shu 2ZHOU Rui 2WU Jinfang 1LI Zongfang2
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作者信息

  • 1. Department of Obstetrics and Gynecology, Second Affiliated Hospital, Medical College, Xi'an Jiaotong University, Xi'an 710004, Shaanxi, China
  • 2. Department of General Surgery, Cadres' Ward, Second Affiliated Hospital, Medical College, Xi'an Jiaotong University, Xi'an 710004, Shaanxi, China
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Abstract

Objective:To analyze the effect of spleen on the Treg cells during pregnancy.Methods:The mononuclear cells were separated from the peripheral,spleen and uterus or placenta blood.Flow cytometry was employed to analyze the percent of Treg cells in total T cells in different stages of pregnancy.Immunohistochemical staining was used to make sure the distribution of Treg in spleen in different stages of pregnancy.Results:The results of immunohistochemical staining showed that compared with spleen Treg cells in normal unpregnant mice,spleen Treg cells on day 7 and 14 of pregnancy significantly increased.After splenectomy,peripheral blood and placenta Treg cells on day 7 ofpregnancy markedly decreased as compared with the normal pregnancy (P＜0.01).And the cells on day 14 of pregnancy were markedly recovered as compared with the normal pregnancy.Conclusion:Our study indicated that the spleen and its Treg cells might play important roles in transient tolerance during pregnancy.

Key words

Spleen/Treg cells/Splenectomy/Pregnancy/Mouse

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基金项目

Supported by National Natural Science Foundation of China(81070536)

出版年

2013
中国人民解放军军医大学学报(英文版)
第一(现南方医科大学),二,三,四军医大学

中国人民解放军军医大学学报(英文版)

影响因子：0.245
ISSN：1000-1948
参考文献量1
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