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中国人民解放军军医大学学报（英文版）
中国人民解放军军医大学学报（英文版）

朱诚 王正国 周树复 姚开泰

双月刊

1000-1948

jydxxb@yahoo.com.cn

021-81870791

200433

上海市翔殷路800号

中国人民解放军军医大学学报（英文版）/Journal Journal of Medical Colleges of PLA
查看更多>> 《军医大学学报》（英文版）是由四所军医大学（原第一军医大学现更名为南方医科大学）共同主办的我军高级医药学综合性英文学术刊物，创刊于1986年6月，初为季刊，2003年改为双月刊，采用标准A4开本、正文64页、铜版纸印刷，彩图随文。现为中国科技论文统计源期刊，并被美国《化学文摘》、俄罗斯《文摘杂志》等国际著名检索系统收录。该刊以反映四所军医大学最新的基础和临床医学研究成果为主，旨在加强国际间的学术交流，扩大和提高我国我军和军医大学的学术影响和地位。主编及编委会成员由四所院校的专家教授共同组成，编辑部成员也由四校相关编辑人员共同组成（联络办公室设在第二军医大学），由四校轮流承担责任主编工作。辟有专家论坛、基础研究、临床研究、经验交流、短篇报道、个案报告等栏目。
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    Effect of ALA-PDT on the expressions of MMP-9, MMP-13 and TIMP-1 of hypertrophic scar model in rabbit ears

    ZHOU PengjunWANG QiongLI ZhangjunXIAO Shengxiang...
    321-334页
    查看更多>>摘要：Objective:To investigate the effect of 5-aminolevulinic (ALA)-photodynamic therapy (PDT) on the expressions of MMP-9,MMP-13 and TIMP-1 of hypertrophic scar model in rabbit ears,and analyze the possible therapeutic mechanisms of ALA-PDT treatment to hypertrophic scars of rabbit ears.Methods:The experimental animals were randomly divided into normal control,negative control,high concentration of ALA-PDT,low concentration of ALA-PDT and PDT groups.The latter three groups received ALA-PDT treatment or PDT treatment once a week for 3 weeks.The specimens of the rabbits were collected respectively 1,2 and 3 months after treatment to be used for RT-PCR and Western-blot test.Results:1,2 and 3 months after PDT treatment,the expressions of MMP-9 and MMP-13 (including mRNA and protein) in hypertrophic scar tissues of three treatment groups were significantly higher than those of the negative control group (P＜0.01),and the expression of TIMP-1 mRNA and protein of three treatment groups were significantly lower than that of the negative control group (P＜0.01).There were also significant differences between high-concentration ALA-PDT treatment group and the low one (P＜0.05).Conclusion:ALA-PDT is effective in treating hypertrophic scars of rabbit ears,and its possible therapeutic mechanisms are that ALA-PDT treatment generates oxidation activation effect to activate the activity of MMPs and induces the photoaging of fibroblasts of hypertrophic scar tissues of rabbit ears to inhibit the activity of TIMPs,which causes the up-regulation of MMPs and the down-regulation of TIMPs.Because of this,the degradation of collagen and ECM is accelerated and the formation of scars is suppressed.
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    Comparison in vitro permeation of curcumin from topical gels by liquid chromatography tandem mass spectrometry

    SUN JunHAN JinzhaoCHENG YaqinLI Zhen...
    335-344页
    查看更多>>摘要：Objective:To frnd a more effective method of topical transdermal delivery of curcumin.Methods:We prepared curcumin carbopol (CRB) 974P and hydroxypmpylcellulose (HPC) gel formulations containing menthol or Azone as permeation enhancers.In this study,negative mode electrospray ionization and a triple quadruple LC/MS/MS instrument operated in multiple reaction mode was used for curcumin detection.The assay was linear over a concentration range of 10 ng/mL to 400 ng/mL for curcumin (average R2 =0.997 2).Excised nude mouse dorsal side skin was used in an in vitro skin permeation study performed using the method of Franz.Results:Our results showed that all of the topical gel formulations we developed were free from skin irritation.The percutaneous flux and enhancement ratio of curcumin across nude mouse epidermis were enhanced markedly by the addition of menthol or Azone to both types of gel formulations.We found that the HPC gels containing quantities of Azone showed an enhanced permeation effect as compared to gels containing menthol.In the case of HPC gels containing Azone,the increase in permeability was significant (P＜0.05) as compared to the gels containing menthol.Conclusion:Azone shows a significantly more remarkable permeation effect than menthol.As such,this novel delivery strategy offers significant promise and is worthy of further exploration in attempts to enhance the medicinal application of curcumin.
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    Effect of amlodipine combined with telmisartan or compound amiloride on plasma ET-1 concentration and left ventricular diastolic function of essential hypertension patients with left ventricular hypertrophy

    YIN YanrongWANG XinWANG YapingZHANG Yong...
    345-354页
    查看更多>>摘要：Objective:To observe the effect of different combination antihypertensive therapies on plasma endothelin-1 (ET-1)concentration and left ventricular diastolic function of essential hypertension patients with left ventricular hypertrophy (LVH).Methods:A total of 111 patients with essential hypertension were selected,including 60 cases (34 males,26 females) aged (60.7±5.6) years with simple hypertension,and 51 cases (28 males,23 females) aged (61.8+ 7.0) years with essential hypertension complicated with LVH.Essential hypertension patients with LVH were randomly divided into the group of amlodipine (2.5 mg/d)combined with telmisartan (40 mg/d,n=26) and the group of amlodipine (2.5 mg/d) combined with amiloride (half tablet/d,n=25),and the treatment listed for 1 year.Echocardiography was performed before and after the treatment.Left ventricular mass index (LVMI),left ventricular isovolumic relaxation time (IVRT) and other indicators were detected,and plisma ET-1 concentrations were measured for comparative analysis.And 56 patients (31 males,25 females) aged (59.3+6.7) years with normal blood pressure in the same period in our hospital were selected as the normal control group.Results:The general clinical characteristics were similar between hypertensive LVH group,simple hypertensive group and normal healthy control group.Plasma ET-1 concentrations,LVMI and IVRT of hypertensive LVH group were significantly higher than those of normal control group and simple hypertension group,and the difference was statistically significant.The patients' baseline blood pressure,ET-1,LVMI,interventricular septal thickness (IVST),left ventricular posterior wall thickness (LVPWT),left ventricular end-diastolic diameter (LVEDd) and other clinical parameters showed no significant difference (P＞0.05) between the group of amlodipine combined with telmisartan and the group of amlodipine combined with amiloride.It was found that compared with that before treatment,blood pressure could be effectively controlled (P＜0.05),and LVMI,IVST,LVPWT and IVRT (P＜0.05) were all lowered,and ET-1 (P＜0.01) was significantly reduced after 1 year of antihypertensive therapy in both the group of amlodipine combined with telmisartan and the group ofamlodipine combined with amiloride.The group ofamlodipine combined with telmisartan was better in lowering blood pressure and reducing LVMI,IVST,LVPWT,IVRT and ET-1 than the group of amlodipine combined with amiloride (P＜0.05).Conclusion:Amlodipine-based combination antihypertensive therapy could reverse LVH and improve left ventricular diastolic function partly by lowering blood pressure and ET-1,and the effect of amlodipine combined with telmisartan was superior to that ofamlodipine combined with amiloride.
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    Xenogeneic hepatic progenitor cell transplantation ameliorate CC14/partial hepatectomy-induced rat acute liver failure

    WAN ZhenLü YiZHANG XiaogangZHENG Xing-long...
    355-367页
    查看更多>>摘要：Objective:Hepatic progenitor cell transplantation has shed light on the treatment of liver failure.The present study was designed to evaluate whether xenogeneic liver epithelial progenitor cells (LEPCs) transplantation could promote liver recovery in a rat model of acute liver failure.The engraftment and hepatocytic differentiation of transplanted hepatic progenitor cells in the rat spleen was also investigated.Methods:LEPCs were propagated in vitro for long and transduced with lentiviral vector carrying mCherry gene.Intraperitoneal injection of CC14 followed by 2/3 partial hepatectomy three days later were used to establish rat models of acute liver failure.Rats were intrasplenically injected with mCherry modified LEPCs (n=20,1x 107 cells/0.5 mL) or the same volume of medium (n=20).Serum liver enzymes (ALT,AST) and liver histology were evaluated for 21 days after transplantation.The engraftment of transplanted LEPCs in the spleens was tested by polymerase chain reaction (PCR) amplification targeting mCherry gene.The differentiation into hepatocytic lineage of transplanted LEPCs was investigated usingimmunohistochemistry staining against Alb.Results:LEPCs were effectively transduced with lentiviral vector showing a transduction efficiency of 90％.Compared with control,cell-injected group displayed significantly lower levels of ALT and AST (P＜0.05) and better histological features including less swelling change and hepatocyte death.PCR amplification of mCherry sequences confirmed the engraftrment of LEPCs in the spleens.Alb-positive cells first appeared 5 days after cell transplantation and the number of Alb-positive cells increased substantially (P＜0.05),which revealed the hepatocytic differentiation process.Conclusion:Xenogeneic hepatic progenitor cells can engraft and differentiate into hepatocytes in the splenic parenchyma.Intrasplenic delivery of hepatic progenitor cells ameliorates CCh/partial hepatectomy-induced liver injury in rats.
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    Effect of ziprasidone on QTc interval in Chinese patients with schizophrenia

    YANG XiaoboYUAN ZuyiCAO HongmeiMA Xiancang...
    368-372页
    查看更多>>摘要：Objective:To investigate the effect of ziprasidone on QTc in Chinese patients with schizophrenia.Methods:The study involved 27 patients with schizophrenia.Ziprasidone was initiated with 40 mg/day.From day 3 to day 7,the dose was increased gradually to 120-160 mg/d according to the effectiveness and tolerability.QTc values were measured at the beginning and month 6.Resullts:At the beginning of the 6 months treatment,the mean QTc interval of patients was (387.5i19.0) ms.At the end of the study,it was (402.9±23.6) ms.The difference has statistically significance (P＜0.05).The mean QTc interval changed significantly throughout 6-months period but no one exceed the QTc dangerous limits.Significant correlation was found between QTc interval and the dose.Conclusion:In summary,our results suggest that ziprasidone has good tolerance in patient with schizophrenia despite its dose-related QTc prolongation.Ziprasidone have no pro-arrhythmic profile.
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    Role of cyclooxygenase-2 in lipid metabolism in hepatic stellate cells

    JING XinyanYANG XuefengOU YangyanQING Kai...
    373-383页
    查看更多>>摘要：Hepatic stellate cells (HSCs) are a kind of adipocytes.In HSCs lipids mainly exist in the form of lipid droplets.They are abundantly found in the cytoplasm and their main constituents are triglycerides.Lipid metabolism in HSCs is closely related to its biological activity,however the mechanism of lipid droplets disappearance after HSC activation is not clearly established yet.Recent research shows that,cyclooxygenase-2 plays an important regulatory role in the lipid metabolism of HSCs.This paper seeks to review the subject based on studies that have been conducted so far to understand the role of cyclooxygenase-2 in the metabolism of lipids in HSCs.
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    Primary malignant pulmonary paraganglioma: a case report and literature review

    YANG YuYANG XinhuiSU Jiali
    384-389页
    查看更多>>摘要：Paragangliomas are very rare rumors arising from neuroectodermal-derived paraganglion tissue.This tumor can be found in any part of the body where healthy paraganglia are known to occur.Malignant pulmonary paraganglioma is distinctly uncommon.We report here a case pathologically proven primary pulmonary paraganglioma with pulmonary metastases and tumor thrombus in a 25-year-old woman.In the patient,non-enhanced pulmonary CT showed a right lung hilar large mass measured 64mm×80mm with a lobulated margin and several nodules close to the pleura.Because of pulmonary metastases and tumor thrombus,the patient had no chance of operation.A bronchial pulmonary artery perfusion chemotherapy and radiotherapy were given.The observation of treatment effect was undergoing.In addition,we review the literature on the topic of pulmonary paraganglioma,management ofparagangliomas involving lung.
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    Multiple biliary adenomas in extrahepatic bile duct: a case report and literature review

    PAN YaminPAN JiGUO Likun
    390-394页
    查看更多>>摘要：Biliary adenoma is uncommon benign neoplasm of the biliary system,of unknown aetiology and account for approximately 0.1％-2％ of all gastrointestinal benign tumors.Most of patients are asymptomatic; a few patients have mild jaundice or abdominal discomfort.To our knowledge,there were only a few cases ofbiliary papillomatosis reported in the previous literatures,which only showed solitary tumor in bile duct.We presented a rare case with multiple biliary adenomas in extrahepatic bile duct confirmed by endoscopic retrograde cholangiopancreatography (ERCP) and histopathology.After 3 months follow-up,the patient remained asymptomatic.
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