Abstract
Objective:To investigate the effect of ziprasidone on QTc in Chinese patients with schizophrenia.Methods:The study involved 27 patients with schizophrenia.Ziprasidone was initiated with 40 mg/day.From day 3 to day 7,the dose was increased gradually to 120-160 mg/d according to the effectiveness and tolerability.QTc values were measured at the beginning and month 6.Resullts:At the beginning of the 6 months treatment,the mean QTc interval of patients was (387.5i19.0) ms.At the end of the study,it was (402.9±23.6) ms.The difference has statistically significance (P＜0.05).The mean QTc interval changed significantly throughout 6-months period but no one exceed the QTc dangerous limits.Significant correlation was found between QTc interval and the dose.Conclusion:In summary,our results suggest that ziprasidone has good tolerance in patient with schizophrenia despite its dose-related QTc prolongation.Ziprasidone have no pro-arrhythmic profile.
基金项目
Natural Science Foundation of Shaanxi Province(2011JM4008)
NETL
NSTL
万方数据