新疆疆岳驴乳粉增强小鼠免疫功能的研究
Immune function influence of Xinjiang Jiangyue Donkey Milk Powder on immunodepressed mice
王红娟 1郑峥 1杨洁1
作者信息
- 1. 新疆大学生命科学与技术学院,乌鲁木齐830046
- 折叠
摘要
探讨驴乳冻干粉对环磷酰胺所致小鼠免疫功能低下的影响.环磷酰胺诱导小鼠免疫功能低下,给小鼠饲喂不同剂量的驴乳冻干粉,并于30 d后测定免疫指标.结果表明:饲喂驴乳粉后,小鼠的T淋巴细胞阳性率由免疫低下组的23.89％上升至驴乳高剂量组的55.70％;白细胞数量由免疫低下组的4.36上升至高剂量组的9.21；吞噬率由免疫低下组的20.9％提高到高剂量组372％,吞噬指数由免疫低下组的0.31提高到驴乳高剂量组的0.62;小鼠胸腺指数由免疫低下组的0.012上升到高剂量组的0.02;CD4+/CD8+比例由免疫低下组的0.82提高到高剂量组的1.81,血清IgG质量浓度由免疫低下组的0.453 g/L提高到高剂量组的0.727 g/L.驴乳不仅能提高机体的免疫能力,而且对环磷酰胺所造成的免疫低下具有缓解作用.
Abstract
To observe the donkey milk powder on immunodepression induced by cydophosphamide in mice. The immunodepression was induced by cydopho'sphamide ,the different dose of donkey milk powder were given to mice for 30 days and measure parameters . The masculine ratio of T lymphocytes increased from 23.89% of immundepressed group to 55.70% of high-dose donky milk group;WBC number increased from 4.36 of immundepressed group to 9.21 of high—dose donky milk group;Phagocytosis rate increased from 20.9% of the immundepressed group to 37.2 %,Phagocytic index increased from 0.31 of immundepressed group to 0.62 of high-dose group of donky milk, increased by nearly two times ;Thymus index increased from 0.012 of immundepressed group to 0.02 of high-dose donky milk group; CD4+/CD8+ rate increased from 0.62 of immundepressed group to 1.81 of high-dose group of donky milk, igG increased from 0.453 of the immundepressed group to 0.727. Donkey milk powder can improve the immunity,and alleviate immunodepression caused by cydophosphamide in mice.
关键词
驴乳粉/环磷酰胺/免疫低下小鼠/免疫调节Key words
donkey milk powder/cyclophosphamide/immunodepressed mice/immune function modulate引用本文复制引用
基金项目
新疆维吾尔自治区自然科学基金(2010211A04)
自治区科技支疆项目计划项目(201191255)
出版年
2012
NETL
NSTL
维普
万方数据