To investigate the auxiliary improvement effect of pure milk of native docosahexaenoic acid on learning memory impairment in mice.Methods:SPF-grade Kunming mice were set up as two models,normal mice and memory acquisition impairment model mice,each containing a control group,low(6.67 mg/kg BW),medium(13.33 mg/kg BW)and high(40.00 mg/kg BW)dose groups.After each group was continuously gavaged for 30 d,the mice in each group were tested for their learning and memory abilities in the jumping platform,dark avoidance and water maze experiments.The results of the jumping platform experiment showed that the test period latency was significantly longer(P＜0.05)and the number of errors was highly significant(P＜0.01)in the middle and high dose groups of the model compared to the model control group;the results of the dark avoidance experiment showed that compared with the negative control group in the dark avoidance experiment,the number of errors and the number of erroneous animals in the fading period of the middle dose group were significantly reduced(P＜0.05);the results of the water maze experiment showed that the total time to the end point was significantly reduced(P＜0.05)in the model medium dose group compared with the model control group.Pure milk of native docosahexaenoic acid may serve as an auxiliary improvement of learning and memory impairment in mice by prolonging the test latency and reducing the number of errors and the number of erroneous animals.
关键词
二十二碳六烯酸/学习记忆/东莨菪碱/多不饱和脂肪酸
Key words
docosahexaenoic acid/learning and memory/scopolamine/polyunsaturated fatty acids
维普
万方数据