Staphylococcus aureus(S.aureus)infects bovine mammary glands,causing inflammation,which aggravates the loss of dairy farming.Studies have found that probiotics have a certain effect on relieving bovine mastitis,which is safer and more effective than antibiotics.In this paper,the pathogenic mechanism of S.aureus,the mechanism and application of probiotics in bovine mastitis were reviewed.It is clear that S.aureus releases virulence factors,in which mucin helps pathogenic bacteria to colonize the cell surface,and at the same time,a large number of S.aureus produces biofilm to destroy the cell structure and trigger a"cytokine storm",which interferes with the immune system recognition.After S.aureus invaded bovine Mammary Epithelial Cells(bMEC),it activated the signal pathway and the expression of related proteins.By analyzing the interference fac-tors of S.aureus'survival in bMEC,it could destroy the epithelial cell barrier and interfere with the immune system.From the point of view of pro-biotics,it is summarized that colonization of probiotics in vivo can enhance intestinal integrity,inhibit the growth of pathogenic bacteria,improve the immunity of the body,thus inhibiting the adhesion and infection of S.aureus to bMEC,reducing the formation of S.aureus biofilm,reducing the colonization of S.aureus in the breast,and thus reducing breast infection.
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