Milk fat globule membrane(MFGM)contains a variety of functional proteins and polar lipids,which can have important positive effects on human health.Such as reducing intestinal diseases,contributing to brain development,improving immunity,regulating metabolism,strength-ening muscle and exercise capacity,etc.This article reviewed the clinical studies and safety evaluation of MFGM in four age groups,including in-fants,children,adults,and the elderly.It aims to provide a theoretical basis for the research of MFGM and the development of MFGM products.