This study investigated the regulatory effects of Lactiplantibacillus plantarum CCFM8661 on immune function and intestinal microbiota in cyclophosphamide-induced immunosuppressed mice.Sixty BALB/c mice were randomly divided into 5 groups:blank control,model control,low-dose CCFM8661(2×106 CFU),medium-dose CCFM8661(2×107 CFU),and high-dose CCFM8661(2×108 CFU).The mice were treat-ed for 30 days,and immune function was evaluated by measuring thymus index,hemolysis plaque assay,spleen index,splenic lymphocyte prolifer-ation,paw swelling degree,half hemolysis value,phagocytic capacity of liver and spleen macrophages,phagocytic rate of peritoneal macrophages,NK cell activity,T lymphocyte subsets,and intestinal microbiota.The results showed that Lactiplantibacillus plantarum CCFM8661 significantly en-hanced immune function in mice and regulated the intestinal microbiota.It was concluded that Lactiplantibacillus plantarum CCFM8661 has a signifi-cant immune-enhancing effect,providing a theoretical basis for the development of immune-modulating health foods.
Lactiplantibacillus plantarum CCFM8661immunosuppressionimmune regulationintestinal microbiota
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