Lactiplantibacillus plantarum CCFM8661 and Bifidobacterium animalis subsp.lactis XLTG11 combined probiotics enhance immune system function
Investigating the impact of a dual-probiotic blend comprising Bifidobacterium animalis subsp.lactis XLTG11 and Lactiplantibacillus plan-tarum CCFM8661 on the immunomodulatory capacity in CTX-induced immunodeficient mice,male BALB/c rodents were selectively allocated into a control cohort and a model group,along with separate low,moderate,and high-dose experimental factions(gavaged with 5×107,5×108,5× 109 CFU/mL of combined probiotics,respectively)for a continuous experiment of 30 days.Throughout the experimental period,the assessment of cellular immunity,humoral immunity,and nonspecific immunity in mice was conducted.Mice in the combined probiotics group displayed a re-markable upsurge in their thymus and spleen indices,ear edema,splenic lymphocyte proliferative capacity,serum hemolysin levels,NK cell activi-ty,and macrophage phagocytosis index when compared to the model group,showing different dose effects,among which the medium and high dose effects were the most obvious.Compared with the model group,the middle-dose group could increase the thymus index by 39.08％(P＜0.001),spleen index by 22.08％(P＜0.05),and NK cell activity by 26.47％(P＜0.001).The high-dose group could increase the degree of ear swelling by up to 84.54％(P＜0.01),the proliferative capacity of splenic lymphocytes by 55.53％(P＜0.01),and the level of serum hemolysin by 12.17％(P＜0.01).The carbon profile phagocytosis index of the low and middle-dose groups increased respectively by 58.51％,58.59％(P＜0.001).While the low dose group could increase the capacity of abdominal macrophages by 57.75％(P＜0.01).In summary,the composite probiotic com-posed of Bifidobacterium animalis subsp.lactis XLTG11 and Lactiplantibacillus plantarum CCFM8661 can significantly improve improve the immune function of mice,thereby offering valuable insight for the formulation of immunostimulatory functional foods..
combined probioticsBifidobacterium animalis subsp.lactis XLTG11Lactobacillus plantarum CCFM8661cyclophosphamideimmune regulation
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