Immunity-enhancing effect of Lactobacillus paracasei Glory LP16 on cyclophosphamide-induced immunosuppressed mice in vivo
The article explores the in vivo improvement effect of Lactobacillus paracasei Glory LP16 on cyclophosphamide(CTX)induced immuno-suppression in mice.An immunosuppression model was established by injecting CTX,and mice were orally gavaged with low,medium,and high doses of Lactobacillus paracasei Glory LP16(1.5×106 CFU/only,1.5×107 CFU/only,and 1.5×108 CFU/only,respectively)for 30 consecutive days.The initial and final body weights,immune organ indices,cellular immune function,humoral immune function,and nonspecific immune effects were measured in the mice.The results indicate that the body weights,immune organ indices,specific immune functions,and nonspecific immune functions were all increased in all experimental groups,with the high-dose group showing extremely significant statistical differences(P＜0.01)in these increases.Based on these findings,it is speculated that Lactobacillus paracasei Glory LP16 can enhance the immune function of mice.
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