首页|江苏省某监测点家畜来源肠致病性大肠埃希菌分离株分子特征分析

江苏省某监测点家畜来源肠致病性大肠埃希菌分离株分子特征分析

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目的 分析江苏省某监测点家畜来源肠致病性大肠埃希菌分离株分子特征,进而评估其潜在的致病性,为感染性腹泻的监测与防控提供依据.方法 采用全基因组测序技术对江苏省某监测点分离的家畜来源的37株肠致病性大肠埃希菌(EPEC)菌株进行特征性分析.结果 本地家畜来源的EPEC均为非典型EPEC(aEPEC),其血清型多样,携带多种与腹泻相关的毒力基因,有9种ST型且具有区域性流行特征,eae基因包含有5种亚型,β1为优势亚型,其在腹泻病人中也最为常见.结论 aEPEC对公众健康构成潜在威胁,应在感染性腹泻的监测工作中,加强对家畜粪便及养殖环境的监测.
Molecular characteristics of enteropathogenic Escherichia coli isolates from livestock at a monitoring point in Jiangsu Province
This study was aimed at analyzing the molecular characteristics of enteropathogenic Escherichia coli(E.coli)strains isolated from domestic animals at a surveillance site in Jiangsu province and evaluating their potential pathogenicity,to provide evidence supporting the surveillance,prevention,and control of infectious diarrhea.Thirty-seven EPEC strains isolated from domestic animals at this surveillance site were characterized by whole genome sequencing.All EPEC strains isolated from local livestock were aEPEC,which has a variety of serotypes and carries a variety of virulence genes associated with diarrhea.Nine ST types with regional epidemic characteristics were identified.Five eae gene subtypes were found,among which β1 was dominant and was also the most common strain in patients with diarrhea.According to analysis of the characteristics of 37 EPEC strains,all EPEC strains from local livestock were aEPEC,thus posing a potential threat to public health.Monitoring of livestock feces and the breeding environment must be strengthened in the surveillance of infectious diarrhea.

enteropathogenic Escherichia coliinfectious diarrheamolecular characteristic analysis

孔筱筱、韩悦、周璐、程晓庆、董晨

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国家卫生健康委员会肠道病原微生物重点实验室,江苏省疾病预防控制中心,南京 210009

杭州远大生物制药有限公司,杭州 310000

肠致病性大肠埃希菌 感染性腹泻 分子特征分析

十四五流行病学重点学科

ZDXK202250

2024

中国人兽共患病学报
中国微生物学会

中国人兽共患病学报

CSTPCD北大核心
影响因子:0.814
ISSN:1002-2694
年,卷(期):2024.40(1)
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