非编码RNA在沙眼衣原体感染中的作用
Roles of non-coding RNAs in Chlamydia trachomatis infection
龚思露 1邹燕2
作者信息
- 1. 湖南中医药大学第二附属医院检验科,长沙 410005
- 2. 湘潭市妇幼保健院检验科,湘潭 411100
- 折叠
摘要
沙眼衣原体(Chlamydia trachomatis,Ct)是一类具有独特发育周期的专性胞内寄生菌,其感染可致泌尿生殖道感染和性病淋巴肉芽肿等多种疾病.非编码RNA(non-coding RNA,ncRNA)是一类不编码蛋白质并具有众多功能的RNA分子,在细胞增殖、凋亡、信号转导以及免疫调控等多种生物学过程中发挥重要调节作用.研究显示Ct感染可引起宿主ncRNA差异表达并调控感染进程,但ncRNA在Ct感染中的具体作用机制尚不完全清楚.因此,本文就ncRNA在Ct感染中的作用进行简要综述.
Abstract
Chlamydia trachomatis ,an obligate intracellular parasite with a unique developmental cycle,causes various dis-eases,such as urinary and reproductive tract infections,and lymphogranuloma venereum.Non-coding RNA(ncRNAs),RNA molecules that cannot encode proteins,have numerous functions,including important regulatory roles in biological processes such as cell proliferation,apoptosis,signal transduction,and immune regulation.C.trachomatis infection has been found to cause differential expression of host ncRNA and to regulate the infection process.However,the exact mechanisms of ncRNAs in C.trachomatis infection remain unclear.This article provides a brief review of the roles of ncRNAs in C.trachomatis infec-tion.
关键词
沙眼衣原体/非编码RNA/miRNA/lncRNA/circRNAKey words
Chlamydia trachomatis/ncRNA/miRNA/lncRNA/circRNA引用本文复制引用
基金项目
湖南省自然科学基金(2022JJ40324)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据