中国人兽共患病学报2024,Vol.40Issue(4) :384-390.DOI:10.3969/j.issn.1002-2694.2024.00.047

1起由冷链产品引起的新型冠状病毒Omicron BA.2.3.7感染的传播链和基因序列分析

Chain of transmission and gene sequence analysis of SARS-CoV-2 Omicron BA.2.3.7 infection caused by a cold chain product

杨欣欣 陈智伟 陈敏红 贾海梅 张晓阳
中国人兽共患病学报2024,Vol.40Issue(4) :384-390.DOI:10.3969/j.issn.1002-2694.2024.00.047

1起由冷链产品引起的新型冠状病毒Omicron BA.2.3.7感染的传播链和基因序列分析

Chain of transmission and gene sequence analysis of SARS-CoV-2 Omicron BA.2.3.7 infection caused by a cold chain product

杨欣欣 1陈智伟 2陈敏红 2贾海梅 2张晓阳1
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作者信息

  • 1. 福建医科大学附属福州市疾病预防控制中心,福州 350005;福建医科大学公共卫生学院,福州 350122
  • 2. 福建医科大学附属福州市疾病预防控制中心,福州 350005
  • 折叠

摘要

目的 对福建省福州市M区1起由进口冷链产品引起的新型冠状病毒暴发疫情进行溯源及基因序列分析.方法 收集2022年9月6日至9月9日期间M区新冠疫情中全部感染者(8名)以及1份阳性冷链产品样本拭子,进行流行病学调查,对采集到的样本进行实时荧光定量PCR检测,对3例阳性感染者和1份冷链产品样本进行全基因组序列测序分析.结果 该起疫情共有8人感染,均为无症状感染者,4条全基因组序列高度同源,共享75个的核苷酸突变位点,共享55个氨基酸突变位点,且符合谱系BA.2.3.7的特征.结论 本次疫情由未有效防护的工人暴露于污染了新型冠状病毒Omicron BA.2.3.7的进口冷链产品所引起.

Abstract

The aim of this study was to trace to origin of SARS-CoV-2 originating from imported cold-chain products re-sponsible for an outbreak that occurred on September 6-9,2022 in Mawei District,Fuzhou City,Fujian Province,China.Sam-ples from all positively infected persons and one positive sample from a swab of a cold-chain product during the outbreak were collected for gene sequencing.Epidemiological investigations were conducted on all positively infected persons to analyze the chain of transmission of the virus.Nucleic acids were detected by real-time fluorescence quantitative PCR,and the outbreak was characterized by a total of eight positive infections,which were asymptomatic.Whole-genome sequencing of three infected per-sons and one cold-chain product sample identified 75 nucleotides and 55 amino acid mutation sites of the BA.2.3.7 variant,with four highly homologous whole-genome sequences.These results confirmed that the outbreak was caused by exposure to impor-ted cold-chain products carrying the SARS-CoV-2 Omicron BA.2.3.7 strain.

关键词

新型冠状病毒/物传人/冷链/全基因组测序/奥密克戎变种

Key words

SARS-CoV-2/object-to-human transmission/cold chain/whole genome sequencing/Omicron variant

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基金项目

福建省卫生健康委重大科研专项(2021ZD01001)

福建省卫生健康委医学创新项目(2020CXA027)

出版年

2024
中国人兽共患病学报
中国微生物学会

中国人兽共患病学报

CSTPCDCSCD北大核心
影响因子:0.814
ISSN:1002-2694
参考文献量9
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