布鲁氏菌主要外膜蛋白研究进展
Research progress in Brucella main outer membrane proteins
辛雪强 1佟彤 1王玉金 1盛宇杰 1徐正中 2陈祥2
作者信息
- 1. 扬州大学江苏省人兽共患病学重点实验室/江苏省动物重要疫病与人兽共患病防控协同创新中心,扬州 225009
- 2. 扬州大学江苏省人兽共患病学重点实验室/江苏省动物重要疫病与人兽共患病防控协同创新中心,扬州 225009;扬州大学农业农村部农产品质量安全生物性危害因子(动物源)控制重点实验室,扬州 225009
- 折叠
摘要
布鲁氏菌病是一种世界范围流行的细菌性人兽共患传染病,由布鲁氏菌属细菌引起,给畜牧业生产和公共卫生安全带来了极大的威胁.外膜蛋白是布鲁氏菌主要的免疫和保护性抗原,与布鲁氏菌的毒力、免疫调节和胞内寄生等特性密切相关.本文对布鲁氏菌主要外膜蛋白的研究进展予以综述,从而促进对布鲁氏菌抗原特性的理解,为布鲁氏菌新型诊断方法的建立和疫苗设计提供参考.
Abstract
Brucellosis,a worldwide epidemic bacterial zoonotic infectious disease caused by bacteria of the genus Brucella,jeopardizes livestock production and poses a major threat to public health safety.Among the various components of Brucella,the outer membrane proteins play crucial roles as the primary immune and protective antigens.These proteins are closely asso-ciated with Brucella's virulence,regulation of the immune response,and ability to survive and multiply within host cells.This article summarizes recent research progress in the primary outer membrane proteins of Brucella,and offers a synthesized view of the current knowledge landscape.Understanding the antigenic characteristics of Brucella outer membrane proteins may sub-stantially contribute to the establishment of new diagnostic methods and the design of new vaccines,thus potentially leading to more effective prevention strategies against brucellosis.The review provides a reference for future studies and may aid in brucel-losis control efforts.
关键词
布鲁氏菌/外膜蛋白/抗原特性Key words
Brucella/outer membrane proteins/antigenic properties引用本文复制引用
基金项目
国家重点研发计划(2021YFD1800403)
江苏高等学校大学生创新创业训练计划项目(202311117042Z)
江苏高校优势学科建设工程项目(PAPD)()
出版年
2024
国家科技期刊平台
NSTL
万方数据