This study retrospectively analyzed the diagnosis and treatment of 27 cases of Chlamydia psittaci pneumonia di-agnosed through metagenomic second-generation sequencing(mNGS)at the First Affiliated Hospital of Nanchang University between January and December 2021.The clinical manifestations,laboratory tests,chest CT findings,treatment,and progno-sis of the patients were recorded.Among 27 cases of Chlamydia psittaci pneumonia,20 patients had a clear history of contact with poultry.The D-dimer level was significantly higher in critically ill patients than non-critically ill patients.Chest CT scans showed that 59.3％of patients in the severe group had bilateral lung lesions—a percentage significantly higher than that in the non-severe group.Analysis of the lower respiratory tract microbiota between groups revealed that the distribution of microbial species differed,but no significant differences were observed in diversity analysis.Species abundance analysis revealed statistical differences in the species abundance of Chlamydia psittaci,Haemophilus parainfluenzae,Streptococcus Australis,and Streptococcus pneumoniae between groups.Thus,the microbial composition in the lower respiratory tract in patients with se-vere Chlamydia psittaci infection showed changes.
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