Pharmacological Functions,Illicit Abuse and Forensic Appraisal of Etomidate and Its Derivatives
Etomidate is a clinical anesthetics that became popular and rapidly spread in 2022,and was quickly listed in October 2023.After listing,the control of etomidate will be carried out according to narcotic standards.Starting from the newly listed etomidate,this review systematically summarizes the pharmacological functions of etomidate and its clinical derivatives,and outlines the clinical testing and analysis of etomidate and its derivatives,as well as the testing technical specifications in forensic practice and forensic appraisal.Responding to the new drug abuse situation as"substituting drugs for narcotics",work suggestions are proposed from five aspects:tracing the origins of clinical anesthetics and psychotropic drugs,the monitoring of derivatives of narcotics,the filing of raw materials and equipments for narcotics synthesis,the control of new types of narcotics carriers,and the standardization of analyzing methods.The aim is to provide work suggestions and reference for curbing the illegal abuse of clinically legal drugs represented by etomidate,as well as scientific management and effective crackdown on narcotics.