首页|银杏叶片对脑梗死恢复期患者血脂、同型半胱氨酸及颈动脉内膜中层厚度的影响

银杏叶片对脑梗死恢复期患者血脂、同型半胱氨酸及颈动脉内膜中层厚度的影响

扫码查看
目的 观察银杏叶片对脑梗死恢复期患者血脂、同型半胱氨酸(homocysteine,HCY)、颈动脉内膜中层厚度(intima-media thickness,IMT)的影响.方法 选择100例脑梗死恢复期患者,随机分为治疗组和对照组各50例.对照组给予阿司匹林肠溶片0.1 qn,阿托伐他汀钙胶囊20mg qn治疗,治疗组在上述基础上加用银杏叶片1片/次tid.收集2组患者用药前、用药1、3及6个月后的血脂、HCY值及用药前和用药6月后的IMT数据.结果 2组均不能显著改善甘油三酯水平.治疗组高密度脂蛋白胆固醇治疗3、6个月后显著高于对照组对应时间点(P<0.05).2组在治疗1、3、6个月后胆固醇、低密度脂蛋白胆固醇与治疗前水平比较均显著下降(P<0.05),但2组间各时间段比较差异均无统计学意义.治疗组胆固醇水平持续平稳下降,对照组在治疗3个月后胆固醇水平有升高趋势,具有波动性.治疗组在治疗3个月后HCY水平显著低于治疗前,1、3、6个月后HCY水平显著低于对照组(P<0.05).治疗组6个月后IMT显著低于对照组(P<0.05).结论 银杏叶片联合阿托伐他汀降脂,可使高密度脂蛋白胆固醇显著升高,血胆固醇水平平稳下降,减少波动,可降低IMT,更有效保护血管;银杏叶片服用3个月以上可降低HCY水平,改善高同型半胱氨酸血症导致的血管内皮受损,减缓粥样斑块的进程.
Efficacy of Ginkgo laminae on blood lipid, homocysteine and intimamedia thickness in recovery phase of cerebral infarction
Objective To observe the influence of Ginkgo laminae on serum lipid, serum level of homocysteine (HCY) and carotid intima-media thickness (IMT) of patients in recovery phase of cerebral infarction. Methods 100 patients in recovery phase of cerebral infarction were randomly divided into treatment group and control group, with 50 cases in each group. The control group were given aspirin enteric coated tablets 0.1g qn po., atorvastatin calcium capsule 20mg qn po.; the treatment group on the basis of the control group were added Ginkgo laminae, 1 tablet per time, three times daily. The blood liqid and HCY levels pre-treatment and 1, 3 and 6 months post-treatment and IMT value pre-treatment and 6 months post-treatment were collected. Results The triglyceride level had no significantly change in two groups. The high density lipoprotein cholesterol 3, 6 months post-treatment in treatment group was significantly higher than control group(P<0.05). The cholesterol and low density lipoprotein cholesterin 1 ,3, 6 months post-treatment in two groups significantly decreased compared with pre-treatment(P<0.05), while there was no significant difference between two groups at each time point. The cholesterol in treatment group had a smooth decreasing, while it had an increasing trend in control group 3 months post-treatment. The HCY 3 months post-treatment in treatment group was significantly lower than pre-treatment and control group 1, 3 and 6 months post-treatment (P<0.05). The IMT 6 months post-treatment in treatment group was significantly lower than control gorup(P<0.05). Conclusion Ginkgo laminae combined with atorvastatin for reducing lipid, which could raise high density lipoprotein cholesterol and reduce cholesterol smoothly and lower IMT, with the effective protection on vessel. The blood homocysteine level decreases after taking Ginkgo laminae for three months, which also could improve impaired endothelial function induced by high level of HCY and slow down the process of atherosclerotic plaque.

Ginkgo laminaerecovery phase of cerebral infarctionblood lipidcarotid intima-media thickness

苏小玲、裘昊、张丽萍

展开 >

嵊州市中医院 神经科,浙江 嵊州 312400

浙江省中医院 神经科,浙江 杭州 310006

银杏叶片 脑梗死恢复期 血脂 同型半胱氨酸 颈动脉内膜中层厚度

浙江省中西医结合学会临床药学科研立项

2014LYK010

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(1)
  • 7
  • 15