摘要
目的 探讨丹参川芎嗪对急性脑梗死患者外周血中性粒细胞/淋巴细胞比值、神经功能评分及预后的影响.方法 选取嘉兴市第一医院2015年6月~2016年6月收治的125例急性脑梗死的患者作为研究对象,随机分为2组,对照组患者采用急性脑梗死的的常规治疗,观察组患者在对照组患者治疗的基础上联合丹参川芎嗪注射液,所有患者均检测血液中白细胞分类、并采用NIHSS评价患者神经功能,并随访2组患者的预后.结果 治疗后,观察组患者白细胞(×109/L)、中性粒细胞(%)、中性粒细胞/淋巴细胞明显低于对照组患患者;2组患者治疗前,治疗后1、7d NIHSS评分比较无明显差异,治疗14d后观察组患者NIHSS评分为(11.1±3.3)分,明显低于对照组患者.观察组患者死亡6例、残疾3例、独立生活53例,明显优于对照组,差异具有统计学意义(P<0.05).结论 丹参川芎嗪有助于降低中性粒细胞/淋巴细胞比值,能改善急性脑梗死患者神经功能、改善患者预后.
Abstract
Objective To investigate effect of Salvia miltiorrhiza Ligustrazine on peripheral lymphocyte neutrophil proportion, neurological function score and prognosis in patients with acute cerebral infarction. Methods 125 cases of acute cerebral infarction in our hospital from June 2015 to June 2016 were selected as the research object, randomly divided into two groups, the control group was treated with conventional treatment of acute cerebral infarction, patients in the observation group in the control group patients on the basis of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection, all patients were detected in the blood leukocyte classification, and the NIHSS evaluation of patients with neurological function and prognosis of the two groups of patients. Results After treatment, the observation group of white blood cells in patients with (×109/L), neutrophil (%), neutrophil / lymphocyte was significantly lower than the control group patients, two groups of patients before treatment, after treatment of 1 day and 7 days, two groups of NIHSS score comparison showed no significant difference, after the treatment of 14d patients in the observation group the NIHSS score was (11.1±3.3), which was obviously lower than the control group, the patients in the observation group were six cases death and disability in three cases, 53 cases of independent life, significantly better than the control group, the difference was statistical significance(P<0.05). Conclusion Salvia miltiorrhiza Ligustrazine can help to reduce the ratio of neutrophil / lymphocyte, improve neurological function and improve the prognosis of patients with acute cerebral infarction, and it is worthy of clinical application.
基金项目
浙江省嘉兴市医学重点学科(神经病学)资助(04F-12)
NETL
NSTL
维普
万方数据